Skip to main content

Table 2 The Sorting Intolerant From Tolerant (SIFT) scores of different mutations

From: The prevalence and mechanism of fluoroquinolone resistance in Escherichia coli isolated from swine farms in China

  Topoisomerases and gyrase mutations Efflux-related mutations
Genes gyrA parC parE marR acrR
Sites 83 87 87 87 87 80 84 355 416b 67a 103 29b
Amino acid alterations S D D D D S E I L D G V
L N Y G H I K T F N S G
Proven Scores −4.2 −4.6 −8.3 −6.5 −6.3 −5.8 −3.9 2.9 −3.9 −4.4 1.4 −6.3
Prediction DT DT DT DT DT DT DT NT DT DT NT DT
  1. Note: Score thresholds for prediction: Default threshold is −2.5, variant with a score equal to or below −2.5 are considered “deleterious”, variant with a score above −2.5 are considered “neutral”; QRDR fluoroquinolone resistance determining region, DT Deleterious, NT Neutral; a The novel mutation was found to be associated with fluoroquinolone resistance; bThe mutation has never been reported in China