| Topoisomerases and gyrase mutations | Efflux-related mutations |
---|
Genes | gyrA | parC | parE | marR | acrR |
---|
Sites | 83 | 87 | 87 | 87 | 87 | 80 | 84 | 355 | 416b | 67a | 103 | 29b |
Amino acid alterations | S | D | D | D | D | S | E | I | L | D | G | V |
L | N | Y | G | H | I | K | T | F | N | S | G |
Proven Scores | −4.2 | −4.6 | −8.3 | −6.5 | −6.3 | −5.8 | −3.9 | 2.9 | −3.9 | −4.4 | 1.4 | −6.3 |
Prediction | DT | DT | DT | DT | DT | DT | DT | NT | DT | DT | NT | DT |
- Note: Score thresholds for prediction: Default threshold is −2.5, variant with a score equal to or below −2.5 are considered “deleterious”, variant with a score above −2.5 are considered “neutral”; QRDR fluoroquinolone resistance determining region, DT Deleterious, NT Neutral; a The novel mutation was found to be associated with fluoroquinolone resistance; bThe mutation has never been reported in China