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Table 2 Values obtained from morphometric analysis of ECM components

From: Interstitial changes after reperfused myocardial infarction in swine: morphometric and genetic analysis

  CONTROL ISCHEMIA WITHOUT REPERFUSION 1-WEEK REPERFUSION 1-MONTH REPERFUSION
  NECROTIC SALVAGED NECROTIC SALVAGED NECROTIC SALVAGED
Collagen I (%) 20.3 ± 10.1 24.3 ± 6.7 18.9 ± 12.1 53.0 ± 10.1** 18.1 ± 12.0 67.1 ± 3.8** 23.0 ± 3.1
Collagen III (%) 16.0 ± 9.3 21.9 ± 8.5 21.6 ± 8.4 24.6 ± 8.5 14.5 ± 8.5 36.6 ± 14.6* 17.9 ± 7.7
Elastic fibers (%) 6.7 ± 1.9 11.2 ± 3.1* 9.1 ± 1.2* 20.3 ± 6.2** 13.6 ± 7.5 16.4 ± 3.0** 12.6 ± 7.4
GAG (%) 10.9 ± 7.1 5.9 ± 1.4 5.1 ± 1.3 29.2 ± 5.0** 16.4 ± 10.0 25.4 ± 8.3** 14.1 ± 6.3
SPARC (%) 2.5 ± 0.6 0.4 ± 0.4 2.1 ± 0.5 6.9 ± 2.0** 1.4 ± 0.9 6.6 ± 1.2** 1.2 ± 0.3
Perlecan (%) 0.7 ± 0.4 0.7 ± 0.2 0.9 ± 0.2 0.3 ± 0.2 0.1 ± 0.2 1.1 ± 0.7 0.4 ± 0.4
Laminin (%) 8.7 ± 0.9 19.8 ± 1.4** 19.5 ± 6.2** 14.3 ± 1.5** 11.5 ± 1.3* 17.7 ± 1.1** 5.5 ± 4.2
Fibronectin (%) 0.1 ± 0.1 2.0 ± 0.8** 0.5 ± 0.4* 13.3 ± 9.8* 0.6 ± 0.7 7.2 ± 4.1** 0.4 ± 0.6
  1. Data were expressed as mean ± SD (n ≥ 5) and were analysed by unpaired t-Student’s test. *P < 0.05, **P < 0.01 vs. control
  2. Abbreviations: ECM Extracellular matrix; GAG Glycosaminoglycan; SPARC Secreted protein acidic and rich in cysteine