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Table 1 Intensity of congestion, mean (± standard deviation) number of mast cells (per mm2), mean (± standard deviation) epithelial thickness of the dorsum and the ventral surface (in microns) and mean (± standard deviation) of the number of nucleoli organizing regions (NORs) in the epithelium of the dorsal and ventral surfaces of the tongue by study group and exposure time (n = 80)

From: Evaluation of buccal damage associated with acute inhalation exposure to 2,4-dichlorophenoxyacetic acid (2,4-D) in mice

Groups*

Congestion

Number of mast cells

Epithelial thickness

Number of NORs

mild

moderate

dorsum

ventral surface

dorsum

ventral surface

SG 1D

5/5 (100%)a

0/5 (0%)a

51.20 (15.04)a

34.55 (9.86)a

22.44 (4.23)a

396.6 (3.78)a

394.2 (13.55)a

SG 2D

5/5 (100%)a

0/5 (0%)a

53.00 (8.65)a

27.85 (7.87)a

27.58 (9.28)a

398 (12.57)a

374 (11.00)a

SG 3D

5/5 (100%)a

0/5 (0%)a

57.4 (11.13)a

30.86 (2.76)a

28.50 (17.07)a

405.8 (20.27)a

378.8 (5.40)a

SG 8D

5/5 (100%)a

0/5 (0%)a

62.2 (14.86)a

27.71 (6.18)a

21.73 (1.99)a

425.4 (20.18)a

359.8 (5.76)a

LCG 1D

5/5 (100%)a

0/5 (0%)a

57.4 (15.72)a

35.11 (5.03)b

24.61 (6.84)a

487.2 (6.97)b

377.8 (10.18)a

LCG 2D

5/5 (100%)a

0/5 (0%)a

57 (16.30)a

28.88 (4.75)a

24.02 (1.80)a

479.6 (11.90)b

363.4 (10.35)a

LCG 3D

5/5 (100%)a

0/5 (0%)a

63.6 (11.55)a

33.61 (6.11)a

25.56 (5.81)a

474.6 (13.93)c

384.8 (5.97)a

LCG 8D

5/5 (100%)a

0/5 (0%)a

46.2 (10.48)a

36.70 (4.60)b

29.70 (6.21)a

467.6 (6.18)c

394.2 (9.88)a

MCG 1D

5/5 (100%)a

0/5 (0%)a

39.6 (12.03)b

35.52 (4.16)b

25.32 (5.44)a

517 (21.62)d

513.4 (4.21)b

MCG 2D

5/5 (100%)a

0/5 (0%)a

59.8 (14.13)a

37.21 (7.29)b

28.68 (4.54)a

508.4 (13.46)d

506.2 (11.54)b

MCG 3D

2/5 (40%)b

3/5 (60%)b

49.6 (10.82)a

36.20 (3.10)b

20.03 (3.03)a

506 (5.33)d

494 (11.00)b

MCG 8D

5/5 (100%)a

0/5 (0%)a

50.8 (17.20)a

31.98 (8.73)a

29.24 (5.01)a

467.6 (1.34)c

394.2 (19.29)a

HCG 1D

3/5 (60%)b

2/5 (40%)b

42.6 (15.63)b

24.07 (5.64)c

23.44 (8.22)a

405.6 (28.93)a

403.2 (22.86)c

HCG 2D

3/5 (60%)b

2/5 (40%)b

40.2 (5.27)b

30.81 (8.47)a

27.70 (6.42)a

461 (13.13)c

387.2 (21.56)a

HCG 3D

5/5 (100%)a

0/5 (0%)a

44 (12.18)b

38.41 (4.52)b

26.76 (3.52)a

444.8 (20.46)d

410 (27.16)c

HCG 8D

3/5 (60%)b

2/5 (40%)b

32.2 (12.98)b

35.97 (3.22)b

23.93 (5.22)a

466 (10.93)c

377.2 (11.71)a

  1. *Groups: SG saline group; LCG low 2,4-D concentration group; MCG middle 2,4-D concentration group; HCG high 2,4-D concentration group; 1D one nebulization; 2D two nebulizations; 3D three nebulizations; 8D eight days after three nebulizations. Different lowercase letters means p-value < 0.05, where: a ≠ b, c, d; b ≠ a, c, d; c ≠ a, b, d; and d ≠ a, b, c. Lowercase letters compare the groups at the same time and in the same column