Fig. 5

Box plots of median and interquartile range (IQR) pp53 Ser392 index. a Hemangioma (median = 0%; IQR =0%) versus hemangiosarcoma (HSA) (median = 53.80%; IQR = 0–69.50%). b Hemangiomas versus well-differentiated HSAs (median = 0%; IQR = 0–53.65%) versus moderately differentiated HSAs (median = 66.90%; IQR = 23.35–70.50%). c Cutaneous vascular tumours without actinic changes (median = 0%; IQR = 0%) versus with actinic changes in the skin (median = 58.70%; IQR = 0–70.30%). d Stage I HSAs (median = 65.15%; IQR = 52.78–79.65%) versus stage II HSAs (median = 12.80%; IQR = 0–67.90%). e HSA size≤5 cm (median = 53.80%; IQR = 0–69.33%) versus HSA > 5 cm (median = 23.35%; IQR = 0–65.30%). Mann-Whitney U test (a, c, d, e) and Mann-Whitney pairwise comparisons (b) were applied for statistical analysis