Fig. 4

Box plots of median and interquartile range (IQR) p53 index. a Hemangioma (median = 0%; IQR = 0–20.91%) versus hemangiosarcoma (HSA) (median = 74.61%; IQR = 66.97–82.98%). b Hemangiomas versus well-differentiated HSAs (median = 82.40%; IQR = 66.49–83.17%) versus moderately differentiated HSAs (median = 73.06%; IQR = 67.11–84.32%). c Cutaneous vascular tumours without actinic changes (median = 0%; IQR = 0–11.17%) versus with actinic changes in the skin (median = 73.94%; IQR = 66.05–82.83%). d Stage I HSAs (median = 82.33%; IQR = 66.97–86.77%) versus stage II HSAs (median = 73.06%; IQR = 67.53–82.40%). e HSA size ≤5 cm (median = 74.61%; IQR = 66.11–82.54%) versus HSA > 5 cm (median = 77.93%; IQR = 68.91–91.39%). Mann-Whitney U test (a, c,e), Mann-Whitney pairwise comparisons(b) and Student t test (d) were applied for statistical analysis