Fig. 1
Model calibration results. Comparisons of model predictions (solid lines) and observed data (squares) for flunixin concentrations in the plasma (a), liver (b), kidneys (c), urine (d), and oral fluids (e) of finishing-age pigs following intramuscular injection with 2.2 mg/kg flunixin meglumine. Only observed data that were higher than limit of quantification (LOQ = 5 ng/ml) are shown. Measured flunixin concentrations in the muscle at 24 h were < LOQ in two animals and not found in one animal, which was consistent with the simulated data (4.70 ng/g) that was <LOQ. At 96 h after injection, observed flunixin concentrations in liver, kidneys, or muscle were all not found, which also corresponded to simulated results (5.03, 2.26, 0.08 ng/g in liver, kidneys, and muscle, respectively). Panel f represents the regression analysis result between measured and simulated data. The regression coefficient was R2 = 0.91, suggesting high overall goodness-of-fit