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Table 2 List of upregulated genes related to ECM

From: Chromatin run-on sequencing analysis finds that ECM remodeling plays an important role in canine hemangiosarcoma pathogenesis

ECM proteins

 

log2 fold change

FDR

COL5A3

Collagen type V alpha 3 chain

4.1598

6.87E-06

COL18A1

Collagen type XVIII alpha 1 chain

3.5531

5.90E-06

COL15A1

Collagen type XV alpha 1 chain

3.4661

3.79E-06

COL1A1

Collagen alpha-1(I) chain

3.2225

7.54E-05

COL3A1

Collagen type III alpha 1 chain

3.1839

2.31E-05

COL16A1

Collagen type XVI alpha 1 chain

2.8378

1.37E-05

COL27A1

Collagen type XXVII alpha 1 chain

2.6061

0.0001001

COL5A2

Collagen type V alpha 2 chain

2.5905

1.21E-05

COL6A3

Collagen type VI alpha 3 chain

2.4047

0.00016717

COL6A2

Collagen type VI alpha 2 chain

2.3539

0.00022812

COL24A1

Collagen type XXIV alpha 1 chain

2.1612

9.72E-05

COL6A1

Collagen type VI alpha 1 chain

2.1272

0.0003894

COL4A2

Collagen type IV alpha 2 chain

1.7088

0.00033908

POSTN

Periostin

6.7428

1.01E-07

SPP1

Secreted phosphoprotein 1;Osteopontin

4.6241

2.73E-05

LAMA4

Laminin subunit alpha 4

3.7745

1.58E-09

LAMB4

laminin subunit beta-4

2.1244

4.93E-05

FN1

Fibronectin

2.7327

2.75E-06

LAMC2

Laminin subunit gamma 2

2.4019

0.00041187

ECM binding protein

log2 fold change

FDR

LUM

Lumican

4.9497

0.00013751

ITGA2

Integrin subunit alpha 2

3.1184

0.00031867

ITGA6

Integrin subunit alpha 6

2.3456

4.69E-05

DDR2

Discoidin domain receptor tyrosine kinase 2

2.1874

0.00011485

BGN

Biglycan

2.1703

0.00022031

ITGA5

Integrin subunit alpha 5

1.9946

1.61E-06

PDPN*

Podoplanin

3.6171

6.43E-05

ECM related enzyme

log2 fold change

FDR

ADAMTS14

ADAM metallopeptidase with thrombospondin type 1 motif 14

3.5027

1.30E-08

ADAM12

ADAM metallopeptidase domain 12

3.0033

1.90E-10

TLL1

Metalloendopeptidase

3.2116

0.00023572

ADAMTS4

ADAM metallopeptidase with thrombospondin type 1 motif 4

2.7526

0.00018318

TIMP1

Metalloproteinase inhibitor 1

2.4316

0.00021979

P4HA2

Prolyl 4-hydroxylase subunit alpha 2

1.7259

2.73E-06

PLOD1

Procollagen-lysine,2-oxoglutarate 5-dioxtgenase 1

1.6827

0.0001534

MMP14

Matrix metalloproteinase

1.6784

6.43E-07