Fig. 6

Immunohistochemical localization of LAMA4 protein in HSA and normal splenic samples. a LAMA4 detection was low to absent in normal splenic tissue (B297, normal white pulp). b anti-LAMA4 staining appears weak in endothelial cells of blood vessels that are adjacent to tumor masses (B783). c and d anti-LAMA4 staining is strong in tumor cells within the tumor’s vascular regions (B848). In these regions the LAMA4-positive tumor cells are seen to surround what appears to be collagen bundles. LAMA4 was also detected in tumor cells from the more avascular regions of the tumor (Supplemental materials). c = low magnification, d = high magnification. Scale bar represents 50 μm