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Fig. 1 | BMC Veterinary Research

Fig. 1

From: Changes in retinal layer thickness with maturation in the dog: an in vivo spectral domain - optical coherence tomography imaging study

Fig. 1

Changes in retinal layer thicknesses with age in the 4 regional quadrants and area centralis.a. Confocal scanning laser ophthalmoscopy (cSLO) image of a left eye fundus indicating the sites at which retinal layer thicknesses were measured. b. Representative SD-OCT high resolution cross-section image of the retina in the dorsal quadrant in a 12-week-old dog with adjacent bars showing the different layers measured: total retina (TR), Receptor+ (REC+), inner retina (IR), and outer nuclear layer (ONL). c-f. The mean (+/− SD) thicknesses of the measured retinal layers in the dorsal (c), ventral (d), nasal (e) and temporal (f) quadrants with age. Each dataset is fitted with a linear regression model. All layers in each of the regions thinned between 4 and 12 weeks of age. A repeated measures correlation showed there was a significant linear correlation between decrease in thickness of each of the four layers in each of the regions and age. See Additional file 1 - Tables S2A and S2B for r and p-values, respectively, as well as Additional file 1 - Tables S1A and S1B for raw values and percentage changes with age respectively. g. Representative SD-OCT high resolution cross-section images of the retina in the area centralis in a 12-week-old dog with adjacent bars showing the different layers measured: total retina (TR), Receptor+ (REC+), inner retina (IR), and outer nuclear layer (ONL). Note the thicker IR layer in the area centralis region compared to the IR thickness in the dorsal region (b). h. The mean (+/− SD) thicknesses of the measured retinal layers in the area centralis with age. Each dataset is fitted with a linear regression model. IR thinned to about 8 to 10 weeks of age while the REC+ thickened over this period and the ONL and TR showed little change in thickness with age. See Additional file 1 - Tables S1A and S1B for raw values and percentage changes with age respectively, as well as Additional file 1 - Tables S2A and S2B for r and p-values, respectively

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