TY - JOUR AU - Schut, Corinne H. AU - Farzan, Abdolvahab AU - Fraser, Russell S. AU - Ainslie-Garcia, Margaret H. AU - Friendship, Robert M. AU - Lillie, Brandon N. PY - 2020 DA - 2020/05/15 TI - Identification of single-nucleotide variants associated with susceptibility to Salmonella in pigs using a genome-wide association approach JO - BMC Veterinary Research SP - 138 VL - 16 IS - 1 AB - Salmonella enterica serovars are a major cause of foodborne illness and have a substantial impact on global human health. In Canada, Salmonella is commonly found on swine farms and the increasing concern about drug use and antimicrobial resistance associated with Salmonella has promoted research into alternative control methods, including selecting for pig genotypes associated with resistance to Salmonella. The objective of this study was to identify single-nucleotide variants in the pig genome associated with Salmonella susceptibility using a genome-wide association approach. Repeated blood and fecal samples were collected from 809 pigs in 14 groups on farms and tonsils and lymph nodes were collected at slaughter. Sera were analyzed for Salmonella IgG antibodies by ELISA and feces and tissues were cultured for Salmonella. Pig DNA was genotyped using a custom 54 K single-nucleotide variant oligo array and logistic mixed-models used to identify SNVs associated with IgG seropositivity, shedding, and tissue colonization. SN - 1746-6148 UR - https://doi.org/10.1186/s12917-020-02344-0 DO - 10.1186/s12917-020-02344-0 ID - Schut2020 ER -