Table 1 Virulence of rSC0012(pS-SaoA) in 3-week-old BALB/c mice
Strain | Description | LD50 (CFU) | |
|---|---|---|---|
Oral | i.p | ||
C78–3 | Wild type | 9.5 × 102 | < 10 |
rSC0018(pS-SaoA) | ΔasdA33 in a live attenuated S. Choleraesuis vaccine strain C500 | > 2.8 × 109 | 6.6 × 106 **, ## |
rSC0012(pS-SaoA) | ΔPfur88::TT araC PBADfur Δpmi-2426 ΔrelA199::araC PBADlacI TT ΔasdA33 in C78–3 | > 5.8 × 109** | 2.1 × 107 **, ## |
rSC0011(pS-SaoA) | ΔPcrp527::TT araC PBADcrp Δpmi-2426 ΔrelA199::araC PBADlacI TT ΔasdA33 in C78–3 | > 1.0 × 109** | 5.4 × 105 ** |