TY - JOUR AU - Chen, Bo AU - Lin, Susanne Je-Han AU - Li, Wen-Ta AU - Chang, Hui-Wen AU - Pang, Victor Fei AU - Chu, Pei-Yi AU - Lee, Chin-Cheng AU - Nakayama, Hiroyuki AU - Wu, Ching-Ho AU - Jeng, Chian-Ren PY - 2020 DA - 2020/05/06 TI - Expression of HIF-1α and VEGF in feline mammary gland carcinomas: association with pathological characteristics and clinical outcomes JO - BMC Veterinary Research SP - 125 VL - 16 IS - 1 AB - The microenvironment within solid malignant tumors, including feline mammary gland carcinomas (FMGCs), is commonly hypoxic, possibly due to the lack of functional blood vessels in rapidly proliferating neoplastic tissue. Malignant cells can undergo genetic and adaptive changes that prevent them from dying due to oxygen deprivation through expressions of hypoxia-inducible factor 1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF). Therefore, HIF-1α and VEGF are ideal biomarkers for cancer therapy and prognostic evaluation. The aims of this study were to evaluate the expression of HIF-1α and VEGF in feline mammary carcinomas and analyze their correlations with clinical and pathological factors, such as clinical stage, histologic grading, regional metastasis, and overall survival rate. SN - 1746-6148 UR - https://doi.org/10.1186/s12917-020-02338-y DO - 10.1186/s12917-020-02338-y ID - Chen2020 ER -