Skip to main content

Table 3 MIC results of test agents against veterinary mycoplasma type strains

From: Efficacy data of halogenated phenazine and quinoline agents and an NH125 analogue to veterinary mycoplasmas

 

MIC (μM) for the following compounds

QC Drug μM, (μg/mL)

No. (%) AMCs w/ MICs ≤25 μMf

Organism

4f

10

11f

12

14

15

19

20

21

Enrofloxacin

 

M. alligatoris

> 12.5

> 25

> 12.5

25

> 25

> 25

> 25

18.8a

25

0.17, (0.06)

3 (33.3)

M. agassizii

> 12.5

> 25

> 12.5

> 25

> 25

25

> 25

> 25

18.8a

0.04–0.17, (0.02–0.06)

2 (22.2)

M. canis

> 12.5b

> 25

> 12.5b

> 25

> 25

> 25

> 25b

> 25d

12.5a

0.17–0.35, (0.06–0.13)

1 (11.1)

M. capricolum

> 12.5

> 25

> 12.5

12.5

> 25

> 25

25

12.5

25

0.4–0.7, (0.13–0.25)

4 (44.4)

M. gallisepticum

> 12.5

> 25

> 12.5

6.25a

> 25

> 25

> 25

18.8a

12.5

0.04, (0.016)e

3 (33.3)

M. pulmonisc

> 12.5

12.5

12.5

12.5a

12.5

> 25

> 25

> 25

12.5a

0.17–0.35, (0.06–0.13)

5 (55.5)

No. (%) AMCs with MICs ≤25 μMf

0

1(16.7)

1 (16.7)

4 (66.7)

1 (16.7)

1 (16.7)

1 (16.7)

3 (50)

6 (100)

  1. aMedian MIC value from multiple, independent tests
  2. bCFU for organism: 1.6 × 105 against this test compound
  3. cCFU/mL range or organism: 4.3 × 104–4.4 × 105, CCU/mL: 104–106
  4. dDrug MIC confirmed via agar dilution
  5. eUsed either enrofloxacin or tylosin tartrate for QC drug
  6. fCompounds 4 and 11 tested up to 12.5 μM
  7. QC-quality control; AMC-antimicrobial compounds