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Table 4 The probabilities of target attainment (PTAs) for typical AUC24h/MIC targets at each possible MIC in HTM broth

From: Epidemiological and PK/PD cutoff values determination and PK/PD-based dose assessment of gamithromycin against Haemophilus parasuis in piglets

Typical AUC24h/MIC targets (h) aPTA (%) at each possible MIC (mg/L) in HTM broth b
0.0630.1250.250.51.02.04.0
15.810010010095.931.20.780.17
30.310010096.737.21.350.180.06
41.210099.585.43.310.570.120.05
  1. aAUC24h/MIC target required to produce bacteriostatic (15.8 h), bactericidal (30.3 h) and eradication (41.2 h) effects in serum
  2. bThe scaling factor that bridged the MICs between HTM and serum has been taken into account when calculating the PTA
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