Epidemiological and PK/PD cutoff values determination and PK/PD-based dose assessment of gamithromycin against Haemophilus parasuis in piglets

Table 4 The probabilities of target attainment (PTAs) for typical AUC_24h/MIC targets at each possible MIC in HTM broth

Typical AUC_24h/MIC targets (h) ^a	PTA (%) at each possible MIC (mg/L) in HTM broth ^b
Typical AUC_24h/MIC targets (h) ^a	0.063	0.125	0.25	0.5	1.0	2.0	4.0
15.8	100	100	100	95.9	31.2	0.78	0.17
30.3	100	100	96.7	37.2	1.35	0.18	0.06
41.2	100	99.5	85.4	3.31	0.57	0.12	0.05

^aAUC_24h/MIC target required to produce bacteriostatic (15.8 h), bactericidal (30.3 h) and eradication (41.2 h) effects in serum
^bThe scaling factor that bridged the MICs between HTM and serum has been taken into account when calculating the PTA

ISSN: 1746-6148