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Table 3 PK/PD analysis of data acquired from ex vivo time-kill experiments of gamithromycin against a representative strain of H. parasuis LM15 in serums collected from each piglet (n = 6)

From: Epidemiological and PK/PD cutoff values determination and PK/PD-based dose assessment of gamithromycin against Haemophilus parasuis in piglets

Parameter (units) aMean ± SD (min to max)
E0 (log cfu/mL)0.91 ± 0.13 (0.73 to 1.05)
Emax (log cfu/mL)−4.68 ± 0.06 (− 4.78 to − 4.61)
Emax - E0 (log cfu/mL)− 5.59 ± 0.15 (− 5.74 to − 5.39)
EC50 (h)24.3 ± 3.88 (19.5 to 29.9)
Slope (N)4.37 ± 2.12 (2.69 to 8.34)
AUC24h/MIC for bacteriostatic effect (h)15.8 ± 4.43 (12.6 to 24.5)
AUC24h/MIC for bactericidal effect (h)30.3 ± 4.40 (24.3 to 36.4)
AUC24h/MIC for eradication effect (h)41.2 ± 7.48 (32.8 to 52.5)
  1. aE0, the change in log10cfu/mL after 24 h of incubation in the no drug control sample; Emax, difference in greatest amount of bacterial reduction (log10 cfu/mL); EC50 is the AUC24h/MIC producing 50% of the maximal effect; N, the slope of dose-response curve. The bacteriostatic, bactericidal and eradication effects were defined as no change, 3.0 log10 cfu/mL and 4.0 log10 cfu/mL reductions in bacterial densities
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