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Table 1 Summary of data abstraction from the 4 manuscripts qualifying for review

From: A systematic review of surgical margins utilized for removal of cutaneous mast cell tumors in dogs

First author

Fulcher

Pratschke

Seguin

Simpson

Year study published

2006

2013

2001

2004

Study description

Clinical trial

Case series

Case series

Case series

Prospective or retrospective

Prospective

Retrospective

Retrospective

Prospective

Tumor location

Cutaneous any site

Cutaneous and SQ

Cutaneous any site

Cutaneous any site

# dogs (MCTs)

16 (23 MCT)

40 (47 MCT)

55 (60 MCT)

21 (23 MCT)

Study groups

Single arm all had surgery (subgroup analysis where 1 cm margins were assessed also)

Single arm all had surgery

Single arm all had surgery and all PG 2

Single arm all had surgery (subgroup analysis where 1 cm and 2 cm margins were assessed also)

Kiupel grading

n/a

37 tumors low grade, 4 tumors high grade

n/a

n/a

# dogs with PG I with surgery

4

21

0

3

# dogs with PG II with surgery

19

18

55

20

# dogs with PG III with surgery

0

2

0

0

Surgical margins utilized

2 cm lateral, 1 fascial plane deep

Lateral margin proportional to size of tumor. (range 5 mm- 4 cm), minimum 1 well defined fascial plane deep

2-3 cm lateral margins and additional tissue deep to dogs that had incomplete resection of MCT by rDVM

3 cm lateral and 1 fascial plane deep.

Incomplete margin definition

Incomplete MCT at margins or within 1 mm of margins

Incomplete MCT at margins or within 1 mm of margins

Incomplete MCT at margins, complete but close within 1 mm of margins

Incomplete MCT at margins, complete but close within 1 mm of margins

Proportion with incomplete margins

2 cm: 10.5% (both PG2)

1 cm: 0% (PG1); 31.6% (PG2)

14.9%

1.7%

Total 1 cm: 21.7%, 2 cm: 0%, 3 cm 0%

PG1: 1 cm: 0%, 2 cm: 0%, 3 cm: 0%

PG2: 1 cm: 25.0%, 2 cm 0%, 3 cm 0%

Local tumor recurrence rate in dogs treated with surgery alone

0%

2.1% (PG3 tumor with complete margins)

5% (2 complete and 1 incomplete)

0%

Time to tumor recurrence (in cases that tumor recurred)

> 538 days

45 days*

61 days

> 603 days

  1. *Represents value for one dog
  2. MCT Mast cell tumor; PG Patnaik grade; rDVM Referring veterinarian; SQ Subcutaneous; TFI Tumor free interval