From: A systematic review of surgical margins utilized for removal of cutaneous mast cell tumors in dogs
First author | Fulcher | Pratschke | Seguin | Simpson |
---|---|---|---|---|
Year study published | 2006 | 2013 | 2001 | 2004 |
Study description | Clinical trial | Case series | Case series | Case series |
Prospective or retrospective | Prospective | Retrospective | Retrospective | Prospective |
Tumor location | Cutaneous any site | Cutaneous and SQ | Cutaneous any site | Cutaneous any site |
# dogs (MCTs) | 16 (23 MCT) | 40 (47 MCT) | 55 (60 MCT) | 21 (23 MCT) |
Study groups | Single arm all had surgery (subgroup analysis where 1 cm margins were assessed also) | Single arm all had surgery | Single arm all had surgery and all PG 2 | Single arm all had surgery (subgroup analysis where 1 cm and 2 cm margins were assessed also) |
Kiupel grading | n/a | 37 tumors low grade, 4 tumors high grade | n/a | n/a |
# dogs with PG I with surgery | 4 | 21 | 0 | 3 |
# dogs with PG II with surgery | 19 | 18 | 55 | 20 |
# dogs with PG III with surgery | 0 | 2 | 0 | 0 |
Surgical margins utilized | 2 cm lateral, 1 fascial plane deep | Lateral margin proportional to size of tumor. (range 5 mm- 4 cm), minimum 1 well defined fascial plane deep | 2-3 cm lateral margins and additional tissue deep to dogs that had incomplete resection of MCT by rDVM | 3 cm lateral and 1 fascial plane deep. |
Incomplete margin definition | Incomplete MCT at margins or within 1 mm of margins | Incomplete MCT at margins or within 1 mm of margins | Incomplete MCT at margins, complete but close within 1 mm of margins | Incomplete MCT at margins, complete but close within 1 mm of margins |
Proportion with incomplete margins | 2 cm: 10.5% (both PG2) 1 cm: 0% (PG1); 31.6% (PG2) | 14.9% | 1.7% | Total 1 cm: 21.7%, 2 cm: 0%, 3 cm 0% PG1: 1 cm: 0%, 2 cm: 0%, 3 cm: 0% PG2: 1 cm: 25.0%, 2 cm 0%, 3 cm 0% |
Local tumor recurrence rate in dogs treated with surgery alone | 0% | 2.1% (PG3 tumor with complete margins) | 5% (2 complete and 1 incomplete) | 0% |
Time to tumor recurrence (in cases that tumor recurred) | > 538 days | 45 days* | 61 days | > 603 days |