Table 1 A schematic of the study timeline including the standard protocol items as defined by the 2013 SPIRIT statement [23, 24]

Enrollment

Eligibility screen

x

Informed consent

x

Randomization and allocation

x

Intervention

Standardized workup

x

x

x

Standardized therapy

x

x

x

x

x

x

x

x

Drug or placebo (q8h)

x, x, x

Assessment

Complete blood count

x

x

x

x

x

Serum chemistry (LDH, HI, Hb, bilirubin)

x

x

x

x

x

C5b-9 complex

x

x

x

x

x

Residual plasma complement

x

x

x

x

x

Serum haptoglobin concentration

x

x

x

x

x

Erythrocyte bound C3b

x

x

x

x

x

Duration of hospitalization

x

Red cell transfusion requirements

x

Rescue therapy requirements

x

Survival (Alive, died, euthanized)

x

x

x

x

Follow-up

Telephone follow-up

x

x

x