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Table 3 List of significantly changed compounds in sheep from overgrazing group and light grazing group

From: Comparative metabolome analysis of serum changes in sheep under overgrazing or light grazing conditions

Ionization mode

Metabolites

Adduct

VIP

Fold change

P value

Retention time (S)

m/z

Related pathway

ESI (+)

Stearoylcarnitine

(M + H)+

1.5381

1.8064

0.0347

254.1865

428.3754

Fatty acid beta-oxidation

ESI (+)

L-Palmitoylcarnitine

(M + H)+

1.4626

1.6676

0.0158

263.4055

400.3447

Fatty acid beta-oxidation

ESI (+)

Cholic acid

(M + NH4)+

10.7858

3.6272

0.0358

383.6785

426.3243

Primary bile acid biosynthesis

ESI (−)

Taurine

(M-H)-

1.1519

1.3343

0.0687

537.531

124.0072

Primary bile acid biosynthesis

ESI (+)

Adenosine

(M + H-H2O)+

1.2463

2.4131

0.0919

163.891

250.0973

Purine metabolism

ESI (−)

Hypoxanthine (HYPO)

(M-H)-

4.6457

0.4923

0.0350

304.1335

135.0318

Purine metabolism

ESI (−)

L-Tryptophan

(M-H)-

1.1472

0.8695

0.0608

469.231

203.0821

Biosynthesis of proteins

ESI (−)

D-Mannose

(M + CH3COO)-

1.3052

0.7540

0.0746

560.7445

239.0763

Antioxidation

ESI (−)

4-Pyridoxic acid

(M-H)-

3.0237

0.5923

0.0002

69.6135

182.0455

Vitamin B6 metabolism

ESI (+)

4-Pyridoxic acid

(M + H)+

2.9734

0.5609

0.0001

67.7175

184.0648

Vitamin B6 metabolism

ESI (+)

1-Stearoyl-sn-glycerol 3-Phosphocholine (LPC)

(M-H + 2Na)+

1.4861

1.4210

0.0037

283.888

568.3406

Major phospholipid components in serum (liver toxicity)

ESI (+)

1,2-Di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine (DOPC)

(M + H)+

11.7198

0.5475

0.0848

169.062

786.5999

Structure of cell membranes

ESI (+)

Acetylcarnitine

(M + H)+

3.1389

0.8104

0.0811

564.452

204.1271

Related to ammonia concentration

ESI (−)

Salicyluric acid

(M-H)-

2.9182

0.3989

0.0000

302.264

194.0461

Energy metabolism

ESI (−)

Salicylic acid

(M-H)-

7.7978

0.3045

0.0001

64.863

137.0247

Immune function modulation

ESI (−)

DL-Lactate

(M-H)-

11.3476

0.7210

0.0316

413.5235

89.02506

Central carbon metabolism in cancer

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BMC Veterinary Research

ISSN: 1746-6148

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