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Table 3 List of significantly changed compounds in sheep from overgrazing group and light grazing group

From: Comparative metabolome analysis of serum changes in sheep under overgrazing or light grazing conditions

Ionization modeMetabolitesAdductVIPFold changeP valueRetention time (S)m/zRelated pathway
ESI (+)Stearoylcarnitine(M + H)+1.53811.80640.0347254.1865428.3754Fatty acid beta-oxidation
ESI (+)L-Palmitoylcarnitine(M + H)+1.46261.66760.0158263.4055400.3447Fatty acid beta-oxidation
ESI (+)Cholic acid(M + NH4)+10.78583.62720.0358383.6785426.3243Primary bile acid biosynthesis
ESI (−)Taurine(M-H)-1.15191.33430.0687537.531124.0072Primary bile acid biosynthesis
ESI (+)Adenosine(M + H-H2O)+1.24632.41310.0919163.891250.0973Purine metabolism
ESI (−)Hypoxanthine (HYPO)(M-H)-4.64570.49230.0350304.1335135.0318Purine metabolism
ESI (−)L-Tryptophan(M-H)-1.14720.86950.0608469.231203.0821Biosynthesis of proteins
ESI (−)D-Mannose(M + CH3COO)-1.30520.75400.0746560.7445239.0763Antioxidation
ESI (−)4-Pyridoxic acid(M-H)-3.02370.59230.000269.6135182.0455Vitamin B6 metabolism
ESI (+)4-Pyridoxic acid(M + H)+2.97340.56090.000167.7175184.0648Vitamin B6 metabolism
ESI (+)1-Stearoyl-sn-glycerol 3-Phosphocholine (LPC)(M-H + 2Na)+1.48611.42100.0037283.888568.3406Major phospholipid components in serum (liver toxicity)
ESI (+)1,2-Di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine (DOPC)(M + H)+11.71980.54750.0848169.062786.5999Structure of cell membranes
ESI (+)Acetylcarnitine(M + H)+3.13890.81040.0811564.452204.1271Related to ammonia concentration
ESI (−)Salicyluric acid(M-H)-2.91820.39890.0000302.264194.0461Energy metabolism
ESI (−)Salicylic acid(M-H)-7.79780.30450.000164.863137.0247Immune function modulation
ESI (−)DL-Lactate(M-H)-11.34760.72100.0316413.523589.02506Central carbon metabolism in cancer