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Table 4 Summary of adapted Hudson and Turner Scores in treated animals

From: Evaluation of new generation macrolides for the treatment and metaphylaxis of contagious bovine pleuropneumonia (CBPP) in cattle experimentally infected with Mycoplasma mycoides subspecies mycoides

Study SiteKenya (VSRI)Zambia (CVRI)
TreatmentSalineTulathromycinGamithromycinOxytetracyclineSalineTulathromycinGamithromycinOxytetracycline
Number of Cattle15 (14*)15151513131314
Mean serology score (s.d.)2.7 (0.8)0.8 (1.2)1.5 (1.4)0.6 (0.8)2.15 (1.28)0.15 (0.55)0.54 (1.05)0.43 (1.09)
Range0–30–30–30–20–30–20–30–3
Mean clinical scorea (s.d.)1.1 (1.5)0 (n/a)0.2 (0.8)0.2 (0.8)0.77 (1.30)000
Range0–300–30–30–3000
Mean post-mortem scoreb (s.d.)5.2 (4.6)0.3 (0.7)1.3 (2.7)0.4 (1.6)5.61 (3.62)001.29 (2.67)
Range0–120–20–90–60–12000–8
Mean adapted Hudson & Turner Score (s.d.)4.5 (2.5)0.8 (1.2)2.0 (2.1)0.9 (1.0)8.54 (4.35)0.15 (0.55)0.54 (1.05)1.71 (3.69)
Range0–80–30–70–30–150–20–30–11
p-value for significance (HT Score)Groups (overall): p ≤ 0.001; s.e. 0.466Groups (overall): p ≤ 0.001; s.e. 0.813 (n = 13); 0.783 (n = 14)
ComparisonGroup 1 vs.Group 2 p ≤ 0.001Group 3 p ≤ 0.001Group 4 p ≤ 0.001Group 1 vsGroup 2 p ≤ 0.001Group 3 p ≤ 0.001Group 4 p ≤ 0.001
  1. a Clinical score calculated as a combination of pyrexia and mortality; b Lesion score calculated as a combination of acute/subacute or chronic lung lesion (type and size) and tissue isolation of Mycoplasma. * Tissue samples for one animal were missing, hence n = 14 for PM and overall adapted HT score