Evaluation of new generation macrolides for the treatment and metaphylaxis of contagious bovine pleuropneumonia (CBPP) in cattle experimentally infected with Mycoplasma mycoides subspecies mycoides

Table 4 Summary of adapted Hudson and Turner Scores in treated animals

Study Site	Kenya (VSRI)				Zambia (CVRI)
Treatment	Saline	Tulathromycin	Gamithromycin	Oxytetracycline	Saline	Tulathromycin	Gamithromycin	Oxytetracycline
Number of Cattle	15 (14*)	15	15	15	13	13	13	14
Mean serology score (s.d.)	2.7 (0.8)	0.8 (1.2)	1.5 (1.4)	0.6 (0.8)	2.15 (1.28)	0.15 (0.55)	0.54 (1.05)	0.43 (1.09)
Range	0–3	0–3	0–3	0–2	0–3	0–2	0–3	0–3
Mean clinical score^a (s.d.)	1.1 (1.5)	0 (n/a)	0.2 (0.8)	0.2 (0.8)	0.77 (1.30)	0	0	0
Range	0–3	0	0–3	0–3	0–3	0	0	0
Mean post-mortem score^b (s.d.)	5.2 (4.6)	0.3 (0.7)	1.3 (2.7)	0.4 (1.6)	5.61 (3.62)	0	0	1.29 (2.67)
Range	0–12	0–2	0–9	0–6	0–12	0	0	0–8
Mean adapted Hudson & Turner Score (s.d.)	4.5 (2.5)	0.8 (1.2)	2.0 (2.1)	0.9 (1.0)	8.54 (4.35)	0.15 (0.55)	0.54 (1.05)	1.71 (3.69)
Range	0–8	0–3	0–7	0–3	0–15	0–2	0–3	0–11
p-value for significance (HT Score)	Groups (overall): p ≤ 0.001; s.e. 0.466				Groups (overall): p ≤ 0.001; s.e. 0.813 (n = 13); 0.783 (n = 14)
Comparison	Group 1 vs.	Group 2 p ≤ 0.001	Group 3 p ≤ 0.001	Group 4 p ≤ 0.001	Group 1 vs	Group 2 p ≤ 0.001	Group 3 p ≤ 0.001	Group 4 p ≤ 0.001

^a Clinical score calculated as a combination of pyrexia and mortality; ^b Lesion score calculated as a combination of acute/subacute or chronic lung lesion (type and size) and tissue isolation of Mycoplasma. ^* Tissue samples for one animal were missing, hence n = 14 for PM and overall adapted HT score

ISSN: 1746-6148