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Table 2 Clinical, serological, pathological, and bacteriological parameters in treated animals

From: Evaluation of new generation macrolides for the treatment and metaphylaxis of contagious bovine pleuropneumonia (CBPP) in cattle experimentally infected with Mycoplasma mycoides subspecies mycoides

Study SiteKenya (VSRI)Zambia (CVRI)
TreatmentSalineTulathromycinGamithromycinOxytetracyclineSalineTulathromycinGamithromycinOxytetracycline
Number of Cattle15 (14*)15151513131314
Max. number of pyrexia days21106111
Number euthanased60113000
Max. CFT titer640 b32032080256020640640
Number with acute/subacute or chronic lesions1434112003
Number (%) with Mycoplasma isolated from tissue, pleural fluid or BAL5/14 (36%)02/15 (13%)1/15 (7%)10/13 (77%)1/13 (8%)2/13 (15%)6/14 (43%)
Number (%) with Mycoplasma isolated from nasal swabs3/15 (20%)1/15 (7%)4/15 (27%)3/15 (20%)2/13 (15%)02/13 (15%)2/14 (14%)
Average HT lesion score (s.d.) a3.40 (2.03)0.33 (0.72)0.67 (1.18)0.40 (1.55)2.54 (1.90)000.57 (1.22)
p-value for significance (lesion scores)Groups (overall): p ≤ 0.001; s.e. 0.375Groups (overall): p = 0.003; s.e. 0.438 (n = 13); 0.423 (n = 14)
ComparisonGroup 1 vs.Group 2 p ≤ 0.001Group 3 p ≤ 0.001Group 4 p ≤ 0.001Group 1 vs.Group 2# (p ≤ 0.001)Group 3# (p ≤ 0.001)Group 4 p ≤ 0.003
  1. *Tissue samples for one animal were missing, hence n = 14 for lesion score. #Appropriate analysis only possible for data for Groups 1 and 4, as 2 and 3 were all negative. However, Groups 2 and 3 are considered to be significantly lower than Group 1 because the 95% CI for Group 1 > zero (approx. 1.5–3.5)
  2. a Lesion score calculated for the size and type of acute or chronic lung lesions. b At VSRI, samples indicating end-point titers beyond 1/640 were not titrated further, in which case the CFT titer was reported as 640