| | MMVD | p-value | Healthy | p-value |
|---|
| CON | CPB | CON | CPB |
|---|
| Total number | 9 | 10 | nd | 8 | 9 | nd |
| Sex (M/F) | 5/4 | 6/4 | nd | 4/4 | 5/4 | nd |
| Age, years | 11.2 (7.9–13.7) | 10.5 (8.1–12.5) | 0.45 | 9.9 (1.6–12.9) | 10.3 (8.1–13.0) | 0.79 |
| Breed (Beagle/Miniature Schnauzer) | 8/1 | 9/1 | nd | 7/1 | 8/1 | nd |
| Physical examination variables |
| Body weight, kg | 10.4 (7.43–12.94) | 9.8 (6.52–12.69) | 0.55 | 11.0 (7.84–13.58) | 12.0 (7.53–15.94) | 0.35 |
| BCS | 5.2 (4–6) | 5.0 (4–6) | 0.48 | 5.8 (5–7) | 5.6 (5–6) | 0.55 |
| Heart rate | 118 (95–140) | 112 (95–153) | 0.57 | 120 (93–152) | 120 (87–156) | 0.99 |
| SAP (mmHg) | 190.8 (150–219) | 171.0 (133–218) | 0.10 | 171.2 (146–211) | 191.9 (164–217) | 0.04 |
| DAP (mmHg) | 104.9 (91–131) | 106.2 (77–133) | 0.84 | 99.5 (77–131) | 114.3 (73–139) | 0.11 |
| Heart murmur grade (1/2/3/4) | 0/4/4/1 | 1/3/5/1 | 0.46 | 0/0/0/0 | 0/0/0/0 | nd |
| ACVIM stages (B1/B2) | 7/2 | 8/2 | nd | 0/0 | 0/0 | nd |
| Echocardiogram variables |
| LAD (cm) | 1.97 (1.47–2.58) | 2.04 (1.39–2.67) | 0.70 | 1.87 (1.46–2.3) | 1.93 (1.37–2.26) | 0.70 |
| LA/Ao | 1.16 (0.91–1.56) | 1.22 (1.1–165) | 0.54 | 1.00 (0.77–1.16) | 1.07 (0.93–1.24) | 0.28 |
| LVD (cm) | 3.11 (2.57–3.57) | 3.17 (2.62–3.59) | 0.69 | 2.92 (2.54–3.38) | 3.00 (2.39–3.49) | 0.64 |
| MVR (m/s) | 5.50 (5.03–6.28) | 5.75 (5.40–6.32) | 0.14 | nd | nd | nd |
| EF (%) | 74 (67–86) | 70 (60–81) | 0.14 | 70 (63–83) | 68 (59–74) | 0.50 |
| MR (none or trace/mild/moderate/severe) | 0/2/5/2 | 0/0/5/5 | nd | 7/1/0/0 | 8/1/0/0 | nd |
- MMVD, myxomatous mitral valve disease; CON, control diet; CPB, cardiac protection blend; BCS, body condition score; LAD, left atrial diameter; LA/Ao, left atrial to aortic root ratio; LVD, left ventricular diameter; MVR, mitral regurgitation velocity; EF, ejection fraction; MR, mitral regurgitation; SAP, systolic arterial pressure; DAP, diastolic arterial pressure; ACVIM, American College of Veterinary Internal Medicine; nd, not detectable or determined. One MMVD dog in the control diet group developed lymphoma after three months and was subsequently removed from the study. Continuous variables are reported as mean (range). P values were calculated using t-test
