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Table 4 Distribution of MIC values and occurrence of resistance in S. suis from Danish pigs

From: Antibiotic resistance in porcine pathogenic bacteria and relation to antibiotic usage

Antimicrobial agent

% Resistant

Distribution (number of isolates) of MICs

  

0.06

0.125

0.25

0.5

1

2

4

8

16

32

64

128

256

512

>512

MIC50

MIC90

A - Distribution of MICs and occurrence of resistance in S. suis (n=448) from pigs, 2004-2007

 Tetracycline

79.5

   

43

49

58

77

9

6

46

160

    

4

>32

 Chloramphenicol

0.2

     

100

318

29

 

1

     

4

4

 Florfenicol

0.9

    

163

277

4

2

2

      

2

2

 Penicillin

1.3

427

6

5

4

4

2

         

≤0.06

≤0.06

 Ceftiofur

0.2

 

423

10

6

5

2

1

1

       

≤0.125

≤0.125

 Trimethoprim

1.8

    

425

4

2

5

 

1

7

    

≤1

≤1

 Sulfametoxazol

         

281

10

2

 

3

152

≤32

>512

 Sulfa-trimethoprim

1.1

  

435

6

2

 

1

 

4

      

≤0.25

≤0.25

 Erythromycin

26.1

  

326

5

3

5

2

3

1

103

     

≤0.25

>16

 Streptomycin

     

5

21

137

134

53

30

68

   

16

>64

 Ciprofloxacin

4.9

 

27

129

225

43

21

1

        

0.5

1

 Spectinomycin

        

358

42

2

4

4

38

 

≤16

64

 Tiamulin

   

48

67

177

100

6

4

6

28

12

    

1

8

B - Distribution of MICs and occurrence of resistance in S. suis (n=331) from pigs, 2008-2011

 Tetracycline

72.2

   

49

43

31

51

7

4

32

114

    

4

>32

 Chloramphenicol

0.6

     

61

240

28

2

      

4

4

 Florfenicol

0.0

    

98

228

5

        

2

2

 Penicillin

0.9

315

3

6

3

3

          

≤0.06

≤0.06

 Ceftiofur

0.0

 

112

10

1

3

2

         

≤0.125

0.25

 Trimethoprim

6.6

   

179

122

7

1

4

3

5

9

    

≤0.5

1

 Sulfametoxazol

         

296

5

2

 

1

27

≤32

64

 Sulfa-trimethoprim

0.0

  

323

6

2

          

≤0.25

≤0.25

 Erythromycin

47.1

  

173

2

1

3

2

3

1

146

     

≤0.25

>16

 Streptomycin

      

19

76

102

36

16

81

   

16

>64

 Gentamicin

   

3

1

1

31

130

35

1

1

     

4

8

 Ciprofloxacin

3.9

 

22

131

139

25

12

1

        

0.5

1

 Spectinomycin

        

229

33

1

1

8

59

 

≤16

>256

 Tiamulin

   

44

60

116

41

7

8

13

23

19

    

1

32

C - Distribution of MICs and occurrence of resistance in S. suis (n=400) from pigs, 2012-2015

 Tetracycline

77.3

   

37

54

59

49

6

12

56

127

    

8

>32

 Chloramphenicol

0.5

     

88

276

34

2

      

4

4

 Florfenicol

0.3

    

140

252

7

  

1

     

2

2

 Penicillin

1.8

370

8

5

9

4

2

1

  

1

     

≤0.06

≤0.06

 Ceftiofur

                  

 Trimethoprim

14.8

   

320

14

7

23

2

3

4

27

    

≤0.5

4

 Sulfametoxazol

         

300

26

18

5

3

48

≤32

>512

 Sulfa-trimethoprim

1.0

  

368

17

5

6

2

 

2

      

≤0.25

≤0.25

 Erythromycin

54.8

  

179

2

1

3

12

8

 

195

     

8

>16

 Streptomycin

      

13

91

112

49

26

109

   

16

>64

 Gentamicin

   

1

1

4

53

233

100

7

1

     

4

8

 Ciprofloxacin

1.8

 

10

171

176

36

6

1

        

0.5

1

 Spectinomycin

        

293

24

1

3

1

78

 

≤16

>256

 Tiamulin

   

54

67

99

86

16

6

14

36

22

    

1

32

D - Distribution of MICs and occurrence of resistance in S. suis (n=151) from pigs, 2016

 Tetracycline

73.5

   

10

30

23

13

1

2

27

45

    

4

>32

 Chloramphenicol

0.7

     

27

117

6

 

1

     

4

4

 Florfenicol

0.7

    

54

95

1

 

1

      

2

2

 Penicillin

0.3

135

1

2

7

4

1

         

≤0.06

≤0.06

 Trimethoprim

21.2

   

115

2

2

11

8

 

2

11

    

≤0.5

8

 Sulfa-trimethoprim

4.6

  

118

6

3

15

3

 

4

      

≤0.25

2

 Erythromycin

51.7

  

72

 

1

 

1

5

72

      

8

16

 Streptomycin

      

14

46

30

15

5

41

   

16

>64

 Spectinomycin

        

92

18

1

 

2

38

 

≤16

>256

 Tiamulin

   

15

12

26

45

9

4

3

18

19

    

2

>32

E - Distribution of MICs and occurrence of resistance in S. suis (n=152) from pigs, 2017

 Tetracycline

75.0

   

13

25

24

29

1

1

17

42

    

4

>32

 Chloramphenicol

0.0

     

23

115

14

       

4

4

 Florfenicol

0.0

    

28

112

2

        

2

2

 Penicillin

2.6

136

4

6

2

4

          

≤0.06

0.125

 Trimethoprim

23.0

   

114

1

1

13

7

 

2

13

    

≤0.5

8

 Sulfa-trimethoprim

8.6

  

122

2

6

9

5

2

3

3

     

≤0.25

2

 Erythromycin

48.0

  

77

1

1

 

1

1

2

69

     

≤0.25

>16

 Streptomycin

      

14

40

26

25

5

42

   

16

>64

 Spectinomycin

        

69

44

  

3

36

 

≤16

>256

 Tiamulin

   

9

12

32

43

9

7

4

21

15

    

2

32