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Table 1 Test results for each marker and the results of ROC analysis

From: Simultaneous evaluation of diagnostic marker utility for enzootic bovine leukosis

Marker*1UnitEBL cattle*2Non-EBL cattle*3, *4Thresholds*5AUC (95%CI)*6Se (%)*7Sp (%)*8
MeanMedian (95 percentile)MeanMedian (95 percentile)
TKDu/L2805.62321 (97.2–10,031.0)23.7312.5 (−70.475–162.8)99.70.98 (0.96–1.00)97.197.0
LDH2IU/L1084.1936.9 (169.5–2602.3)397.8288 (146.2–1244.4)460.60.87 (0.83–0.91)82.881.7
Total LDHIU/L37433038 (812.3–10,010.1)1695.11002 (544.0–7428.8)13890.85 (0.81–0.89)87.575.8
LDH3IU/L693.9634.4 (86.0–1735.7)267.2168.2 (75.2–1048.8)283.70.85 (0.80–0.89)82.279.7
TNFR II/I0.930.68 (0.06–4.15)0.260.17 (0.09–0.80)0.30.85 (0.79–0.90)81.781.8
LDH1IU/L1100.3920.7 (335.6–2708.6)602.7438.5 (270.2–1843.5)564.50.83 (0.79–0.87)82.275.1
LDH4IU/L485.5168.6 (24.9–1330.9)143.663.9 (20.5–829.0)91.60.77 (0.72–0.82)79.374.6
No. of lymphocytes102/ul316.8108 (16.7–2112.0)46.434 (13.0–138.3)75.50.76 (0.70–0.81)61.373.2
PVLcopies/10 ng DNA3289.81969.3 (28.3–16,224.0)1536.6779.9 (0.0–5729.7)3433.10.69 (0.63–0.75)51.972.4
LDH5IU/L289.9466.45 (9.7–1881.9)285.7641.5 (10.5–2574.0)54.50.6 (0.54–0.66)60.962.9
  1. *1 TK: thymidine kinase; LDH: lactate dehydrogenase; TNFR: tumor necrosis factor receptor; PVL: proviral load. *2 EBL cattle: cattle affected with BLV-induced lymphoma; 95 percentile: lower and upper limit of 95 percemtile *3 Non-EBL cattle: cattle without BLV-induced lymphoma (including non-infected cattle) *4 Data from non-infected cattle were not included for statistical analysis of PVL *5 Thresholds were calculated by using receiver operating characteristic (ROC) analysis *6 AUC: Area under the curve at the threshold *7 Se: sensitivity for the detection of EBL cattle at the threshold *8 Sp: specificity for the detection of EBL cattle at the threshold