TY - JOUR AU - Suzuki, Ryohei AU - Mochizuki, Yohei AU - Yuchi, Yunosuke AU - Yasumura, Yuyo AU - Saito, Takahiro AU - Teshima, Takahiro AU - Matsumoto, Hirotaka AU - Koyama, Hidekazu PY - 2019 DA - 2019/10/28 TI - Assessment of myocardial function in obstructive hypertrophic cardiomyopathy cats with and without response to medical treatment by carvedilol JO - BMC Veterinary Research SP - 376 VL - 15 IS - 1 AB - Inconsistency of treatment response in cats with obstructive hypertrophic cardiomyopathy is well recognized. We hypothesized that the difference in response to beta-blockers may be caused by myocardial functional abnormalities. This study was designed to compare myocardial function in cats with obstructive hypertrophic cardiomyopathy with and without response to beta-blockers. Twenty-one, client-owned, hypertrophic cardiomyopathy cats treated with carvedilol were analyzed. After carvedilol treatment, cats with decreased left ventricular outflow tract velocity were categorized as responders (nā€‰=ā€‰10); those exhibiting no response (no decrease in the left ventricular outflow tract velocity) were categorized as non-responders (nā€‰=ā€‰11). The cats were examined using layer-specific assessment of the myocardial function (whole, endocardial, and epicardial layers) longitudinally and circumferentially by two-dimensional speckle-tracking echocardiography, before and after carvedilol treatment. SN - 1746-6148 UR - https://doi.org/10.1186/s12917-019-2141-0 DO - 10.1186/s12917-019-2141-0 ID - Suzuki2019 ER -