TY - JOUR AU - Roels, Elodie AU - Bauer, Natali AU - Lecut, Christelle AU - Moritz, Andreas AU - Gothot, André AU - Clercx, Cécile PY - 2019 DA - 2019/10/29 TI - Haemostatic, fibrinolytic and inflammatory profiles in West Highland white terriers with canine idiopathic pulmonary fibrosis and controls JO - BMC Veterinary Research SP - 379 VL - 15 IS - 1 AB - Canine idiopathic pulmonary fibrosis (CIPF) is a progressive interstitial lung disease mainly affecting old West Highland white terriers (WHWTs). The aetiology of CIPF is currently unknown and pathogenesis poorly understood. A genetic basis is strongly suspected based on the breed predisposition. CIPF shares clinical and pathological features with human IPF. In human IPF, coagulation disorders favouring a local and systemic pro-thrombotic state have been demonstrated in association with disease severity and outcome. The aim of this study was to compare the systemic haemostatic, fibrinolytic and inflammatory profiles of WHWTs affected with CIPF with breed-matched controls (CTRLs). Additionally, data collected in both groups were interpreted with regard to the reference intervals (when available) to assess possible pro-thrombotic features of the WHWT breed that may be related to CIPF predisposition. A total of 14 WHWTs affected with CIPF and 20 CTRLs were included. SN - 1746-6148 UR - https://doi.org/10.1186/s12917-019-2134-z DO - 10.1186/s12917-019-2134-z ID - Roels2019 ER -