Fig. 4
From: Immune inhibitory function of bovine CTLA-4 and the effects of its blockade in IFN-γ production
The immune activating effect of anti-CTLA-4 mAb against bovine leukemia virus (BLV) infected cattle PBMCs. PBMCs (n = 10) of BLV-infected cattle were cultured with 20 μg/ml control antibody or anti-CTLA-4 mAb in the presence of fetal lamb kidney cells (FLK)-BLV antigen for 7 days. FLK was used as a control antigen. The IFN-γ production was measured using an ELISA. The bars indicate the average of each group. Statistical comparisons were made using the Steel-Dwass test. The differences were considered statistically significant at p < 0.05