Fig. 8

Non-specific induction of antiviral immunity in dogs by LTC treatment. Purpose bred beagles (n = 21) shortly after exposure to canine herpesvirus were randomly assigned to treatment groups, with n = 7 receiving a single intranasal and oral LTC treatment, and n = 14 being treated with PBS, as noted in Methods. Dogs were monitored for clinical signs of herpesvirus infection, including conjunctivitis scores, as noted in Methods. The overall mean conjunctivitis score for each group was calculated and plotted. Statistical significance was evaluated by Fisher’s exact test (* = p < 0.05). The majority of clinical signs were recorded in the first 7 days after initiation of treatment (94%) and none of the dogs had clinical signs consistent with canine herpesvirus after Day 13