Table 1 Adverse drug reactions (ADRs) probability scale [6]
From: Malarone® induced pancreatitis and alopecia in a dog: a case report
Questions | Yes | No | Don’t know | Score a) |
|---|---|---|---|---|
1. Are there previous conclusive reports on this reaction? | + 1 | 0 | 0 | 0 |
2. Did the adverse event appear after the suspected drug was administered? | + 2 | −1 | 0 | + 2 |
3. Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered? | + 1 | 0 | 0 | 0 |
4. Did the adverse reaction reappear when the drug was readministered? | + 2 | −1 | 0 | 0 |
5. Are there alternative causes (other than the drug) that could on their own have caused the reaction? | −1 | + 2 | 0 | + 2 |
6. Did the reaction reappear when a placebo was given? | −1 | + 1 | 0 | 0 |
7. Was the drug detected in the blood (or other fluids) in concentrations known to be toxic? | + 1 | 0 | 0 | 0 |
8. Was the reaction more severe when the dose was increased, or less severe when the dose was decreased? | + 1 | 0 | 0 | 0 |
9. Did the patient have a similar reaction to the same or similar drug in any previous exposure? | + 1 | 0 | 0 | 0 |
10. Was the adverse event confirmed by any objective evidence? | + 1 | 0 | 0 | + 1 |
Total score b) | + 5 | |||