|
Time (hours post induction)
|
Control
|
Firocoxib
|
Grapriprant
|
|---|
|
Experiment 1 - treatments administered 2 h prior to induction of arthritis
|
|
1.5
|
0.49 (0.00–0.89)a
|
0.90 (0.73–0.99)
|
0.76 (0.00–1.05)b
|
|
3
|
0.00 (0.00–0.00)c
|
0.86 (0.75–0.98)c
|
0.26 (0.00–0.83)d
|
|
5
|
0.00 (0.00–0.00)c
|
0.80 (0.00–1.04)c
|
0.00 (0.00–0.00)d
|
|
7
|
0.00 (0.00–0.00)c
|
0.95 (0.69–1.05)c
|
0.00 (0.00–0.00)d
|
|
10
|
0.00 (0.00–0.00)c
|
1.06 (0.98–1.17)c
|
0.16 (0.00–0.98)d
|
|
Experiment 2 - treatments administered 14 h prior to induction of arthritis
|
|
1.5
|
0.28 (0.00–0.66)a
|
0.75 (0.00–0.97)
|
0.61 (0.00–1.02)b
|
|
3
|
0.00 (0.00–0.00)
|
0.36 (0.00–0.84)
|
0.00 (0.00–0.65)
|
|
5
|
0.00d (0.00–0.00)d
|
0.45 (0.00–0.99)d
|
0.00 (0.00–0.00)e
|
|
7
|
0.00 (0.00–0.00)c
|
0.80 (0.00–1.07)c
|
0.00 (0.00–0.00)d
|
|
10
|
0.35 (0.00–0.87)f
|
0.91 (0.66–1.05)f
|
0.00 (0.00–0.00)g
|
- Different superscripts in the same row indicate statistically significant differences: a,b p = 0.026; c,d p < 0.001; e,d p = 0.033; f,g p ≤ 0.006
