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Fig. 3 | BMC Veterinary Research

Fig. 3

From: Ivermectin inhibits canine mammary tumor growth by regulating cell cycle progression and WNT signaling

Fig. 3

Effects of ivermectin on cell cycle distribution of canine mammary tumor cells. a Cell cycle distribution was analyzed by flow cytometry after 24 h or 48 h treatment with 8 μM ivermectin. b Cell cycle profiles of CMT7364 and CIPp cells after 24 h or 48 h treatment with 8 μM ivermectin. Data represent the mean. Triplicate wells were used for each treatment. c Western blotting showed the expression of CDK4 and cyclin D1 after 24 h treatment with ivermectin at 8 μM or 12 μM. Similar results were obtained from triplicate wells. Quantitative analysis of CMT 7364 (d) and CIPp (e) in c. Data represent the mean ± SD. *P<0.05; **P<0.01

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