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Table 1 Plasma concentration (ng/mL) of furosemide in plasma from horses treated intravenously with furosemide at 1 mg/kg (n = 4)

From: Pharmacokinetics of furosemide in thoroughbred horses subjected to supramaximal treadmill exercise with and without controlled access to water

Time (h)

Horses treated with furosemide 24 h before supramaximal treadmill exercise with controlled access to water

Time (h)

Horses treated with furosemide 4 h before supramaximal treadmill exercise with controlled access to water

A

F

B

D

A

F

B

D

0

0

0

0

0

0

0

0

0

0

0.1

3678

3666

3525

4021

0.1

3274

3369

3697

5532

0.5

707

574

645

871

0.5

534

669

651

876

1

250

232

272

241

1

197

228

243

685

1.5

94

147

148

149

1.5

121

122

126

166

3

54

131

142

111

3

83

87

92

53

6

ND

113

117

61

6

63

57

64

ND

9

ND

ND

92

55

9

49

ND

37

ND

12

ND

ND

ND

ND

 
  1. ND Furosemide not detected or below the lower limit of quantification (25 ng/mL) of the HPLC_UV method. No furosemide was detected at later time points