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Table 1 Pharmacokinetic parameters of CS (10 mg/kg, i.m.) after fitting two-compartment open model with first-order absorption

From: PK/PD modeling of Ceftiofur Sodium against Haemophilus parasuis infection in pigs

Parameter

Unit

Healthy pigs (n = 8)

Diseased pigs (n = 6)

Ka

1/h

0.489 ± 0.061a

0.537 ± 0.054a

AUC

h·μg/mL

125.646 ± 9.895a

126.498 ± 13.752a

AUMC

h2·μg/mL

2201.958 ± 829.817a

1703.975 ± 442.930a

MRT

h

15.503 ± 7.001a

11.436 ± 2.547a

Cmax

ÎĽg/mL

11.236 ± 0.603a

11.504 ± 0.575a

Tmax

h

2.358 ± 0.286a

2.226 ± 0.146a

T1/2Ka

h

1.456 ± 0.172a

1.281 ± 0.143a

T1/2Ke

h

17.550 ± 8.830a

11.247 ± 2.930a

Vd/F

L/kg

2.402 ± 0.999a

1.649 ± 0.482a

CL/F

mL/h/kg

80.010 ± 6.115a

79.837 ± 8.640a

  1. Ka, absorption rate constant; AUC, area under the concentration-time curve after every administration; AUMC, the area under the first moment of the plasma concentration-time curve; MRT, presented mean residence time; Cmax, the maximum concentration during the dosage interval; Tmax, the time to reach peak concentration; T1/2Ka, absorption half-life; T1/2Ke, elimination half-life; Vd/F, volume of distribution; CL/F, systemic clearance. Different lowercase letters indicate a significant difference (P < 0.05)