Fig. 1From: Experimental study on the effects of isoflurane with and without remifentanil or dexmedetomidine on heart rate variability before and after nociceptive stimulation at different MAC multiples in catsSTD HR correlation with MAC. STD HR values (1/min) of 7 cats determined with isoflurane alone (group I, triangles), with isoflurane and a constant rate infusion of remifentanil (18 μg/kg/h IV; group IR, diamonds) and with isoflurane and a constant rate infusion of dexmedetomidine (3 μg/kg/h IV; group ID, circles) at different MAC levels (0.75, 1.0 and 1.5 MAC). Prestimulation values were used for correlation analysis. The correlation coefficients for STD HR were − 0.76 (p = < 0.0001) in group I, − 0.56 in group IR (p = 0.0085) and in group ID (p = 0.0142) with increasing MAC level. The slopes of the best-fit linear regression lines were − 1.932 (r2 = 0.4644, p = 0.0007) in group I, − 1.669 (r2 = 0.1975, p = 0.0435) in group IR and − 3.189 (r2 = 0.181, p = 0.0784; not significant) in group IDBack to article page