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Fig. 1 | BMC Veterinary Research

Fig. 1

From: Canine platelets express functional Toll-like receptor-4: lipopolysaccharide-triggered platelet activation is dependent on adenosine diphosphate and thromboxane A2 in dogs

Fig. 1

Platelet activation upregulates surface TLR4 expression. Platelet surface TLR4 expression was measured on isolated platelets from 10 dogs using flow cytometry. a,c Representative histograms of resting (unstimulated) platelets (grey) and activated platelets (clear) indicating increase in surface TLR4 expression following thrombin (a) and ADP (c) activation. b Thrombin stimulation led to significant increase in percentage (%) of TLR4-positive platelets compared to resting platelets. d Platelets stimulated with 10 μM ADP had significantly higher percentage of TLR-positive platelets. First and third quartiles were represented by the lower and upper boundaries, respectively. + and the line within the box represents the mean and median, respectively. Whiskers represent the range of data. * p < 0.05

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BMC Veterinary Research

ISSN: 1746-6148

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