TY - JOUR AU - Coronado, Liani AU - Bohórquez, Jose Alejandro AU - Muñoz-González, Sara AU - Perez, Lester Josue AU - Rosell, Rosa AU - Fonseca, Osvaldo AU - Delgado, Laiyen AU - Perera, Carmen Laura AU - Frías, Maria Teresa AU - Ganges, Llilianne PY - 2019 DA - 2019/07/15 TI - Investigation of chronic and persistent classical swine fever infections under field conditions and their impact on vaccine efficacy JO - BMC Veterinary Research SP - 247 VL - 15 IS - 1 AB - Recent studies have hypothesized that circulation of classical swine fever virus (CSFV) variants when the immunity induced by the vaccine is not sterilizing might favour viral persistence. Likewise, in addition to congenital viral persistence, CSFV has also been proven to generate postnatal viral persistence. Under experimental conditions, postnatal persistently infected pigs were unable to elicit a specific immune response to a CSFV live attenuated vaccine via the mechanism known as superinfection exclusion (SIE). Here, we study whether subclinical forms of classical swine fever (CSF) may be present in a conventional farm in an endemic country and evaluate vaccine efficacy under these types of infections in field conditions. SN - 1746-6148 UR - https://doi.org/10.1186/s12917-019-1982-x DO - 10.1186/s12917-019-1982-x ID - Coronado2019 ER -