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Table 3 Gene expression changes (fold change) in the ileum of the different treatment groups compared to non-vaccinated control sheep

From: The humoral immune response is essential for successful vaccine protection against paratuberculosis in sheep

  Non-vaccinated uninfected (n = 10) Non-vaccinated infected (n = 10) Vaccinated control (n = 5) Vaccinated uninfected (n = 18) Vaccinated infected (n = 2)
  aIgG1 (SP%) 0.49 10.75 54.39 91.09 52.2
Up regulated LYN 2.1 1.2   1.4 1.6
GRB2 1.8     1.4
ERG1      
JUN   1.4    1.1
NFIL3   2.2   1.4 2.8
LCK 1.5 3.2    
CD81 1.5 1.9    
CD84   3.8 a    
CD40LG 2.5 5    5
BAFF 1.5 5 b    2.2
MIF 1.1 2.4    1.3
Down regulated LYN    −1.8   
GRB2   −1.2 −3 −1.1  
ERG1 −1.7 −3.8 −3.3 −1.4 −1.7
JUN −1.4   −1.9 − 1.1  
NFIL3 −1.1   −1.6   
LCK    −2.8 −1 − 1.1
CD81    −3.6 −1.6 − 1.2
CD84 −1.1   −2.1 −2.4 a −1.1
CD40LG    −1.1 − 1  
BAFF    −1.2 -1 b  
MIF    −2.9 −1.7  
  1. aIgG1 SP% of each group at the same timepoint as gene expression analysis was performed. Significant differences between groups are indicated by bolding (p < 0.05) with a significantly different to a and b significantly different to b