Table 2 Analysis matrix for sheep B cell-related gene expression in intestinal tissue for specific research questions
Research question | Baseline group | Comparison group (s) |
|---|---|---|
Q1. What gene expression changes are associated with disease outcome in non-vaccinated animals? Are these similar in vaccinated animals? | Non-vaccinated control | Non-vaccinated infected Non-vaccinated uninfected Vaccinated infected Vaccinated uninfected |
Q2. What gene expression changes are associated with disease outcome in vaccinated animals | Vaccinated control | Vaccinated infected Vaccinated uninfected |
Q3. What gene expression changes are associated with infection in vaccinated animals | Vaccinated uninfected | Vaccinated infected |
Q4. What gene expression changes are associated with vaccination nonresponse in infected animals | Non-vaccinated infected | Vaccinated infected |