Table 1 Statistically significant DEPs identified by iTRAQ analysis of MDBK cells infected with CPIV3
Accession | Protein name | CPIV3-infected | Mock-infected | FC (CPIV3-infected vs_Mock-infected) | regulate |
|---|---|---|---|---|---|
Q0VCX2 | Endoplasmic reticulum chaperone BiP (HSPA5) | 1 | 0.488 | 2.049180328 | up |
Q95M18 | Endoplasmin (HSP90B1) | 1 | 0.744 | 1.344086022 | up |
F1MEN8 | Protein disulfide-isomerase A4 (PDIA4) | 1 | 0.816 | 1.225490196 | up |
E1B748 | Hypoxia up-regulated protein 1 precursor (HYOU1) | 1 | 0.704 | 1.420454545 | up |
Q27965 | Heat shock 70 kDa protein 1B (HSPA1B) | 1 | 0.793 | 1.261034048 | up |
A6QR28 | Phosphoserine aminotransferase (PSAT1) | 1 | 0.814 | 1.228501229 | up |
F1MWU9 | Uncharacterized protein (HSPA6) | 1 | 0.726 | 1.377410468 | up |
Q3ZCA7 | G protein subunit alpha i3 (GNAI3) | 1 | 0.739 | 1.353179973 | up |
Q1LZA3 | Asparagine synthetase [glutamine-hydrolyzing] (ASNS) | 1 | 0.721 | 1.386962552 | up |
P80513 | Mesencephalic astrocyte-derived neurotrophic factor (MANF) | 1 | 0.794 | 1.259445844 | up |
Q2KHU0 | Phosphoserine phosphatase (PSPH) | 1 | 0.81 | 1.234567901 | up |
Q3T0L2 | Endoplasmic reticulum resident protein 44 (ERP44) | 1 | 0.765 | 1.307189542 | up |
Q08DL0 | SLC3A2 protein (SLC3A2) | 1 | 0.78 | 1.282051282 | up |
A5PK96 | ACP1 protein (ACP1) | 1 | 0.78 | 1.282051282 | up |
P13909 | Plasminogen activator inhibitor 1 (SERPINE1) | 1 | 0.807 | 1.239157373 | up |
P68301 | Metallothionein-2 (MT2) | 1 | 0.491 | 2.036659878 | up |
Q27955 | Voltage-gated potassium channel subunit beta-2 (KCNAB2) | 1 | 0.797 | 1.254705144 | up |
A5D7C1 | Probable ATP-dependent RNA helicase DDX52 (DDX52) | 1 | 0.814 | 1.228501229 | up |
A6H797 | MLEC protein (MLEC) | 1 | 0.807 | 1.239157373 | up |
F1N1R3 | Mitochondrial ribosomal protein L40 (MRPL40) | 1 | 0.824 | 1.213592233 | up |
E1BPL3 | ATP binding cassette subfamily B member 7 (ABCB7) | 1 | 0.721 | 1.386962552 | up |
A5PJN8 | Splicing factor 3A subunit 2 (SF3A2) | 1 | 0.551 | 1.814882033 | up |
Q2KIN6 | Protein Mpv17 (MPV17) | 1 | 0.801 | 1.248439451 | up |
Q3SZZ0 | Ribosome biogenesis protein BRX1 homolog (BRIX1) | 1 | 0.799 | 1.251564456 | up |
A6QLR4 | Flotillin-2 (FLOT2) | 1 | 0.476 | 2.100840336 | up |
Q17QI2 | RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (SSU72) | 1 | 0.796 | 1.256281407 | up |
Q0VCS9 | Ankyrin repeat and MYND domain-containing protein 2 (ANKMY2) | 1 | 0.812 | 1.231527094 | up |
A2VE10 | Protein CASC4 (CASC4) | 1 | 0.829 | 1.206272618 | up |
A7MB19 | NLRX1 protein (NLRX1) | 1 | 0.804 | 1.243781095 | up |
Q6EVI2 | eIF4GI protein (eIF4GI) | 1 | 0.825 | 1.212121212 | up |
Q3SZ99 | Peptidylprolyl isomerase (AIP) | 1 | 0.774 | 1.291989664 | up |
E1BD11 | Chromosome 11 open reading frame 84 (SPINDOC) | 1 | 0.825 | 1.212121212 | up |
A4FUC0 | 39S ribosomal protein L37, mitochondrial (MRPL37) | 1 | 0.815 | 1.226993865 | up |
Q2TA30 | Ninjurin 1 (NINJ1) | 1 | 0.594 | 1.683501684 | up |
E1BN60 | Solute carrier family 30 member 1 (SLC30A1) | 1 | 0.77 | 1.298701299 | up |
Q3T093 | Adaptin ear-binding coat-associated protein 1 (NECAP1) | 1 | 0.83 | 1.204819277 | up |
G3N3D6 | Phosphoinositide phospholipase C(PLCH1) | 1 | 0.823 | 1.215066829 | up |
Q2YDF6 | 28S ribosomal protein S35, mitochondrial(MRPS35) | 1 | 0.809 | 1.236093943 | up |
Q08DH9 | CCCTC-binding factor(CTCF) | 1 | 0.802 | 1.246882793 | up |
Q08DK7 | Mitochondrial basic amino acids transporter(SLC25A29) | 1 | 0.798 | 1.253132832 | up |
F1MBD5 | Surfeit 2(SURF2) | 1 | 0.833 | 1.200480192 | up |
G3X6N3 | Serotransferrin (TF) | 1 | 0.76 | 1.315789474 | up |
F1MG47 | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (PAOX) | 1 | 0.706 | 1.416430595 | up |
E1BH45 | RB1 inducible coiled-coil 1 (RB1CC1) | 1 | 0.682 | 1.46627566 | up |
E1BMF4 | Kinase D interacting substrate 220 (KIDINS220) | 1 | 0.811 | 1.233045623 | up |
E1BI11 | ELM2 and Myb/SANT domain containing 1 (ELMSAN1) | 1 | 0.736 | 1.358695652 | up |
Q5E9T1 | GDP-D-glucose phosphorylase 1 (GDPGP1) | 1 | 0.823 | 1.215066829 | up |
A7Z023 | CCDC132 protein (CCDC132) | 1 | 0.819 | 1.221001221 | up |
A6QR26 | UBAP1 protein (UBAP1) | 1 | 0.702 | 1.424501425 | up |
A5PJZ7 | Histone deacetylase (HDAC6) | 1 | 0.832 | 1.201923077 | up |
Q148F0 | Ubiquitin-related modifier 1 (URM1) | 1 | 0.402 | 2.487562189 | up |
F1MRI6 | Lemur tyrosine kinase 2 (LMTK2) | 1 | 0.42 | 2.380952381 | up |
Q0V882 | Bax inhibitor 1 (TMBIM6) | 1 | 0.766 | 1.305483029 | up |
G3X6Y2 | Chromosome X open reading frame 38 (CXHXorf38) | 1 | 0.81 | 1.234567901 | up |
G3MYB9 | UNC homeobox (UNCX) | 1 | 0.793 | 1.261034048 | up |
G3N0M5 | Uncharacterized protein | 1 | 0.698 | 1.432664756 | up |
Q3SZN3 | Metalloendopeptidase OMA1, mitochondrial (OMA1) | 1 | 0.304 | 3.289473684 | up |
A7YWG9 | PHLDA1 protein (PHLDA1) | 1 | 0.654 | 1.529051988 | up |
A0JNQ0 | Allograft inflammatory factor 1-like (AIF1L) | 1 | 0.808 | 1.237623762 | up |
Q2YDD1 | FGFR1 oncogene partner (FGFR1OP) | 1 | 0.664 | 1.506024096 | up |
F1MN39 | Interferon related developmental regulator 1 (IFRD1) | 1 | 0.521 | 1.919385797 | up |
Q0II90 | Protein FAM81B (FAM81B) | 1 | 0.118 | 8.474576271 | up |
Q75V95 | Calcitonin receptor-stimulating peptide 1 (CRSP1) | 1 | 0.818 | 1.222493888 | up |
F1MSI9 | Discs large MAGUK scaffold protein 5 (DLG5) | 1 | 0.795 | 1.257861635 | up |
E1BFR6 | Transmembrane protease, serine 13 (TMPRSS13) | 1 | 0.827 | 1.209189843 | up |
E1BC24 | Midasin (MDN1) | 1 | 0.579 | 1.727115717 | up |
Q08DG0 | Nuclear receptor binding factor 2 (NRBF2) | 1 | 0.434 | 2.304147465 | up |
Q2KI89 | LisH domain-containing protein ARMC9 (ARMC9) | 1 | 0.411 | 2.433090024 | up |
F1MNN5 | Sortilin related VPS10 domain containing receptor 1 (SORCS1) | 1 | 0.759 | 1.317523057 | up |
A0A140T882 | Uncharacterized protein CLBA1 (CLBA1) | 1 | 0.635 | 1.57480315 | up |
F1MH73 | Transmembrane protein 131 (TMEM131) | 1 | 0.793 | 1.261034048 | up |
Q28037 | Vitamin D3 receptor (VDR) | 1 | 0.826 | 1.210653753 | up |
F1N2K8 | Periplakin (PPL) | 1 | 1.423 | 0.702740689 | down |
F6RJG0 | 3-hydroxy-3-methylglutaryl coenzyme A synthase (HMGCS1) | 1 | 1.371 | 0.729394602 | down |
Q5KR49 | Tropomyosin alpha-1 chain (TPM1) | 1 | 1.227 | 0.814995925 | down |
G3MWV5 | Histone cluster 1 H1 family member e (HIST1H1E) | 1 | 1.264 | 0.791139241 | down |
A7MAZ5 | Histone H1.3 (HIST1H1D) | 1 | 1.258 | 0.79491256 | down |
Q3SYV6 | Importin subunit alpha (KPNA2) | 1 | 1.22 | 0.819672131 | down |
Q28178 | Thrombospondin-1 (THBS1) | 1 | 1.406 | 0.711237553 | down |
F1N3A1 | Thrombospondin-1 (THBS1) | 1 | 1.555 | 0.643086817 | down |
A4FV94 | KRT6A protein (KRT6A) | 1 | 1.212 | 0.825082508 | down |
A6QPB5 | PGM1 protein (PGM1) | 1 | 1.272 | 0.786163522 | down |
G3N0V2 | Keratin 1 (KRT1) | 1 | 1.499 | 0.667111408 | down |
E1BNE7 | Caveolae associated protein 1 (CAVIN1) | 1 | 1.213 | 0.824402308 | down |
Q3YJF3 | MHC class I antigen (Fragment) (BoLA) | 1 | 1.277 | 0.783085356 | down |
Q2HJJ0 | Kinesin light chain 4 (KLC4) | 1 | 1.209 | 0.827129859 | down |
F1MX88 | Solute carrier family 25 member 13 (SLC25A13) | 1 | 1.212 | 0.825082508 | down |
F1 N688 | V-type proton ATPase subunit B, kidney isoform (ATP6V1B1) | 1 | 1.352 | 0.73964497 | down |
Q0VCZ8 | Acyl-CoA synthetase long-chain family member 1 (ACSL1) | 1 | 1.333 | 0.750187547 | down |
A6QNZ7 | Keratin 10 (Epidermolytic hyperkeratosis; keratosis palmaris et plantaris) (KRT10) | 1 | 1.387 | 0.720980534 | down |
F1N4K3 | Uncharacterized protein | 1 | 1.474 | 0.678426052 | down |
F1MTJ9 | Terpene cyclase/mutase family member (LSS) | 1 | 1.243 | 0.804505229 | down |
Q867D1 | Stearoyl-CoA desaturase (Scd) | 1 | 1.427 | 0.700770848 | down |
F1MH31 | Nucleoporin 214 (NUP214) | 1 | 1.241 | 0.805801773 | down |
G3N1R5 | Uncharacterized protein | 1 | 1.454 | 0.687757909 | down |
Q32PA5 | Ubiquitin-conjugating enzyme E2 C (UBE2C) | 1 | 1.589 | 0.629326621 | down |
Q0P5J6 | Keratin, type I cytoskeletal 27 (KRT27) | 1 | 1.375 | 0.727272727 | down |
A7MB38 | SFRS4 protein (SRSF4) | 1 | 1.22 | 0.819672131 | down |
A7YW33 | DNA polymerase delta interacting protein 3 (POLDIP3) | 1 | 1.267 | 0.789265983 | down |
Q3ZCI0 | Coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD9) | 1 | 1.298 | 0.770416025 | down |
E1BJC9 | Uncharacterized protein (C18H19orf33) | 1 | 1.24 | 0.806451613 | down |
A5D7N6 | Kinesin-like protein (KIF23) | 1 | 1.373 | 0.728332119 | down |
F2Z4H2 | Non-histone chromosomal protein HMG-17 (HMGN2) | 1 | 1.242 | 0.805152979 | down |
A3KLR9 | Superoxide dismutase (SOD3) | 1 | 1.36 | 0.735294118 | down |
G8JKY5 | Thymosin beta-4 (TMSB4X) | 1 | 1.547 | 0.646412411 | down |
Q08DI5 | Ras-related protein Rap-2c (RAP2C) | 1 | 1.207 | 0.828500414 | down |
A4IF70 | GPR56 protein (GPR56) | 1 | 1.233 | 0.811030008 | down |
P15103 | Glutamine synthetase (GLUL) | 1 | 1.265 | 0.790513834 | down |
E1BKT0 | Leucine zipper protein 1 (LUZP1) | 1 | 1.353 | 0.7390983 | down |
F1MFW9 | Keratin 24 (KRT24) | 1 | 2.313 | 0.432338954 | down |
Q0VC74 | Trimethyllysine dioxygenase, mitochondrial (TMLHE) | 1 | 1.217 | 0.821692687 | down |
F1MLZ1 | Cytochrome b reductase 1 (CYBRD1) | 1 | 1.252 | 0.798722045 | down |
F1MP14 | Forkhead box K1 (FOXK1) | 1 | 1.208 | 0.82781457 | down |
F1MYS2 | FCH domain only 2 (FCHO2) | 1 | 1.253 | 0.798084597 | down |
Q3T0J9 | Guanine nucleotide-binding protein-like 3-like protein (GNL3L) | 1 | 1.336 | 0.748502994 | down |
Q2NKZ9 | Carboxypeptidase (SCPEP1) | 1 | 1.206 | 0.829187396 | down |
F1N6L1 | Valyl-tRNA synthetase 2, mitochondrial (VARS2) | 1 | 1.272 | 0.786163522 | down |
G5E5Q8 | SET binding factor 1 (SBF1) | 1 | 1.286 | 0.777604977 | down |
Q2KHW7 | Regulator of G-protein signaling 10 (RGS10) | 1 | 1.219 | 0.820344545 | down |
F1N4R2 | Uncharacterized protein (MORF4L1) | 1 | 1.222 | 0.818330606 | down |
Q5E9Q1 | Protein O-glucosyltransferase 1 (POGLUT1) | 1 | 1.234 | 0.810372771 | down |
Q29RZ9 | WD repeat-containing protein 92 (WDR92) | 1 | 1.26 | 0.793650794 | down |
F1N5R4 | Conserved oligomeric Golgi complex subunit 8 (COG8) | 1 | 1.271 | 0.786782061 | down |
F1ML71 | Nedd4 family interacting protein 2 (NDFIP2) | 1 | 1.254 | 0.797448166 | down |
G3 N266 | G protein signaling modulator 1 (GPSM1) | 1 | 1.235 | 0.809716599 | down |
F1N0K0 | Collagen alpha-1(XI) chain (COL11A1) | 1 | 1.212 | 0.825082508 | down |
F1MGF2 | Chromodomain helicase DNA binding protein 1 (CHD1) | 1 | 1.254 | 0.797448166 | down |
A6QQK2 | MAP3K7IP1 protein (MAP3K7IP1) | 1 | 1.339 | 0.74682599 | down |
E1BDA1 | Ras and Rab interactor 1 (RIN1) | 1 | 1.29 | 0.775193798 | down |
E1B8R7 | HPS5, biogenesis of lysosomal organelles complex 2 subunit 2 (HPS5) | 1 | 1.252 | 0.798722045 | down |
A8E646 | CARD11 protein (CARD11) | 1 | 1.222 | 0.818330606 | down |
Q32KL9 | B-cell receptor-associated protein 29 (BCAP29) | 1 | 1.435 | 0.696864111 | down |
E1BGG6 | Regulatory factor X5 (RFX5) | 1 | 1.233 | 0.811030008 | down |
Q3T0N3 | Calcium load-activated calcium channel (TMCO1) | 1 | 1.295 | 0.772200772 | down |
E1BC89 | Oxysterol-binding protein (OSBPL5) | 1 | 1.241 | 0.805801773 | down |
F1MQ45 | Solute carrier organic anion transporter family member (SLCO2A1) | 1 | 1.234 | 0.810372771 | down |
Q32P76 | Small EDRK-rich factor 1 (SERF1) | 1 | 1.447 | 0.691085003 | down |
A6QQS5 | WHSC2 protein (WHSC2) | 1 | 1.289 | 0.77579519 | down |
F1MNT2 | Protein RTF2 homolog (RTF2) | 1 | 1.278 | 0.782472613 | down |
F1MEY2 | Enoyl-[acyl-carrier-protein] reductase, mitochondrial (MECR) | 1 | 1.387 | 0.720980534 | down |
A6QNX2 | DPP7 protein (DPP7) | 1 | 1.287 | 0.777000777 | down |
E1BE80 | Transmembrane protein 236 (TMEM236) | 1 | 1.247 | 0.801924619 | down |
A4IFD1 | PDCD4 protein (PDCD4) | 1 | 1.209 | 0.827129859 | down |
A1A4R8 | Cell division cycle protein 23 homolog (CDC23) | 1 | 1.267 | 0.789265983 | down |
E1BG49 | Centromere protein E (CENPE) | 1 | 1.324 | 0.755287009 | down |
P07926 | ATP synthase F(0) complex subunit C2, mitochondrial (ATP5MC2) | 1 | 1.497 | 0.668002672 | down |
Q402A0 | Aggrus (PDPN) | 1 | 1.293 | 0.773395205 | down |
Q17QI1 | Trafficking protein particle complex subunit 1 (TRAPPC1) | 1 | 1.265 | 0.790513834 | down |
E1BKA4 | Uncharacterized protein (HAUS4) | 1 | 1.3 | 0.769230769 | down |
Q2KHT6 | F-box only protein 32 (FBXO32) | 1 | 1.227 | 0.814995925 | down |
F1MS44 | Doublecortin domain containing 2 (DCDC2) | 1 | 1.277 | 0.783085356 | down |
E1BIR2 | Dipeptidase (DPEP2) | 1 | 1.211 | 0.825763832 | down |
A5PKA5 | Sorting nexin-27 (SNX27) | 1 | 1.31 | 0.763358779 | down |
A6H7C1 | MORF4L2 protein (MORF4L2) | 1 | 1.213 | 0.824402308 | down |
A6QLZ5 | Protein FAM177A1 (FAM177A1) | 1 | 1.23 | 0.81300813 | down |
P13384 | Insulin-like growth factor-binding protein 2 (IGFBP2) | 1 | 1.748 | 0.57208238 | down |
A5D974 | Acyl-Coenzyme A dehydrogenase family, member 9 (ACAD9) | 1 | 1.217 | 0.821692687 | down |
F1N2N9 | Coiled-coil domain containing 114 (CCDC114) | 1 | 1.224 | 0.816993464 | down |
E1BBH4 | Protein unc-93 homolog B1 (UNC93B1) | 1 | 1.666 | 0.600240096 | down |
A5PJX0 | F-box protein 22 (FBXO22) | 1 | 1.272 | 0.786163522 | down |
E1BEG4 | Zinc finger FYVE-type containing 16 (ZFYVE16) | 1 | 1.225 | 0.816326531 | down |
E1BEI6 | ATM serine/threonine kinase (ATM) | 1 | 1.507 | 0.663570007 | down |
P0C914 | Overexpressed in colon carcinoma 1 protein homolog | 1 | 1.213 | 0.824402308 | down |