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Table 3 Serum chemistry mean values observed in cats treated with oral oclacitinib or placebo

From: A blinded, randomized, placebo-controlled trial of the safety of oclacitinib in cats

Parameter Placebo 1 mg/kg 2 mg/kg
Day −2 Day 7 Day 14 Day 28 Day 42 Day −2 Day 7 Day 14 Day 28 Day 42 Day − 2 Day 7 Day 14 Day 28 Day 42
Alkaline phosphatase (U/l) 33.0 30.2 27.0 27.8 35.1 28.4 25.7 27.5 32.7 32.7 33.7 34.2 33.6 32.3 36.4
 ALT (U/l) 71.2 76.2 87.4 65.5 61.9 75.1 85.5 75.0 76.9 55.7 49.4 54.0 56.0 63.5 60.7
 AST (U/l) 27.6 30.2 29.4 24.2 27.7 31.5 28.9 34.0 32.5 30.7 26.3 31.6 27.7 28.0 34.8
Total bilirrubin (mg/dL) 0.59 1.14 1.21 0.49 0.53 0.56 1.11 0.84 0.42 0.52 0.58 0.50 0.79 0.61 0.55
Direct bilirrubin (mg/dL) 0.32 0.34 0.55 0.23 0.21 0.24 0.54 0.37 0.19 0.20 0.25 0.25 0.36 0.27 0.22
Indirect bilirrubin (mg/dL) 0.27 0.80 0.66 0.26 0.32 0.32 0.57 0.47 0.23 0.32 0.33 0.26 0.43 0.34 0.33
 GGT (U/l) 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.2 0.1 0.0 0.1 0.0
 Glucose (mg/dL) 75.6 76.4 76.0 71.5 77.3 86.0 74.9 74.6 72.2 78.0 87.5 8.7 78.0 72.0 80.9
 Fructosamine (μ mol/l) 244.80 246.63 229.32 252.58 249.90 267.15 267.33a 262.98 263.55 269.82 236.57 252.45a 240.37 238.50 261.95
 Triglycerides (mg/dL) 58.6 65.8 94.0 47.0 62.8 56.2 96.8 76.3 44.4 49.7 54.7 45.2 71.2 51.2 66.8
 Cholesterol (mg/dL) 105.4 11.1 116.3 102.9 108.8 102.7 111.9 116.2 101.8 107.3 106.9 121.8 131.6 112.9 111.5
 Albumin (g/dL) 2.24 2.24 2.40 2.24 2.45 2.25 2.27 2.36 2.15 2.38 2.17 2.26 2.35 2.27 2.40
 Total protein (g/dL) 6.44 6.54 6.86 6.58 6.87 6.70 6.83 6.93 6.23 6.76 6.38 6.51 6.50 6.31 6.63
 Urea (mg/dL) 43.5 44.1 51.1 43.3 42.9 43.6 43.4 48.5 42.8 41.7 42.8 48.40 50.2 45.8 41.5
 Creatinine (mg/dL) 1.25 1.23 1.29 1.36 1.24 1.42 1.30 1.39 1.39 1.34 1.35 1.41 1.36 1.42 1.39
  1. ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, gamma glutamyl transpeptidase
  2. aSignificantly different than placebo value at the same day (p = 0.03)
  3. Reference values: alkaline phosphatase-0-62; ALT-28-76; AST-5-55; total bilirubin-0.1-0.4; direct bilirubin-0.04-0.3; indirect bilirubin-0.01-0.5; GGT-1-7; glucose-70-150; fructosamine- 190-400; triglycerides-20-90; cholesterol-82-218; albumin-2.4-4.1; total protein-5.9-8.5; urea-42.8-64.2; creatinine-0.8-1.6