A blinded, randomized, placebo-controlled trial of the safety of oclacitinib in cats

BMC Veterinary Research

Table 3 Serum chemistry mean values observed in cats treated with oral oclacitinib or placebo

Parameter	Placebo					1 mg/kg					2 mg/kg
Parameter	Day −2	Day 7	Day 14	Day 28	Day 42	Day −2	Day 7	Day 14	Day 28	Day 42	Day − 2	Day 7	Day 14	Day 28	Day 42
Alkaline phosphatase (U/l)	33.0	30.2	27.0	27.8	35.1	28.4	25.7	27.5	32.7	32.7	33.7	34.2	33.6	32.3	36.4
ALT (U/l)	71.2	76.2	87.4	65.5	61.9	75.1	85.5	75.0	76.9	55.7	49.4	54.0	56.0	63.5	60.7
AST (U/l)	27.6	30.2	29.4	24.2	27.7	31.5	28.9	34.0	32.5	30.7	26.3	31.6	27.7	28.0	34.8
Total bilirrubin (mg/dL)	0.59	1.14	1.21	0.49	0.53	0.56	1.11	0.84	0.42	0.52	0.58	0.50	0.79	0.61	0.55
Direct bilirrubin (mg/dL)	0.32	0.34	0.55	0.23	0.21	0.24	0.54	0.37	0.19	0.20	0.25	0.25	0.36	0.27	0.22
Indirect bilirrubin (mg/dL)	0.27	0.80	0.66	0.26	0.32	0.32	0.57	0.47	0.23	0.32	0.33	0.26	0.43	0.34	0.33
GGT (U/l)	0.0	0.1	0.0	0.0	0.1	0.0	0.0	0.2	0.0	0.0	0.2	0.1	0.0	0.1	0.0
Glucose (mg/dL)	75.6	76.4	76.0	71.5	77.3	86.0	74.9	74.6	72.2	78.0	87.5	8.7	78.0	72.0	80.9
Fructosamine (μ mol/l)	244.80	246.63	229.32	252.58	249.90	267.15	267.33^a	262.98	263.55	269.82	236.57	252.45^a	240.37	238.50	261.95
Triglycerides (mg/dL)	58.6	65.8	94.0	47.0	62.8	56.2	96.8	76.3	44.4	49.7	54.7	45.2	71.2	51.2	66.8
Cholesterol (mg/dL)	105.4	11.1	116.3	102.9	108.8	102.7	111.9	116.2	101.8	107.3	106.9	121.8	131.6	112.9	111.5
Albumin (g/dL)	2.24	2.24	2.40	2.24	2.45	2.25	2.27	2.36	2.15	2.38	2.17	2.26	2.35	2.27	2.40
Total protein (g/dL)	6.44	6.54	6.86	6.58	6.87	6.70	6.83	6.93	6.23	6.76	6.38	6.51	6.50	6.31	6.63
Urea (mg/dL)	43.5	44.1	51.1	43.3	42.9	43.6	43.4	48.5	42.8	41.7	42.8	48.40	50.2	45.8	41.5
Creatinine (mg/dL)	1.25	1.23	1.29	1.36	1.24	1.42	1.30	1.39	1.39	1.34	1.35	1.41	1.36	1.42	1.39

ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, gamma glutamyl transpeptidase
^aSignificantly different than placebo value at the same day (p = 0.03)
Reference values: alkaline phosphatase-0-62; ALT-28-76; AST-5-55; total bilirubin-0.1-0.4; direct bilirubin-0.04-0.3; indirect bilirubin-0.01-0.5; GGT-1-7; glucose-70-150; fructosamine- 190-400; triglycerides-20-90; cholesterol-82-218; albumin-2.4-4.1; total protein-5.9-8.5; urea-42.8-64.2; creatinine-0.8-1.6

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