Cell and context-dependent sorting of neuropathy-associated protein NDRG1 – insights from canine tissues and primary Schwann cell cultures

Table 1 Distribution of NDRG1 protein in canine tissues and cells

Organ	Cell type	Epithelial (E) Mesenchymal (M) Neural (N)	NDRG1 staining pattern
Organ	Cell type	Epithelial (E) Mesenchymal (M) Neural (N)	Cytoplasmic^a	Basolateral	Nuclear	Centrosomal
Kidney	Epithelium, proximal tubules	E	+	+
Jejunum, colon	Epithelium	E		+	+	+
Jejunum, colon	Smooth muscle cells	M	+
Lung	Epithelium, bronchioles	E	+	+
Lung	Club cells	E	+
Liver	Epithelium, bile ducts	E	+
Pancreas	Acinar cells	E	+	+	+	+
Ovary	Granulosa cells	E		+
Ovary	Cells of the corpus luteum	E	+
Uterus	Epithelium of the endometrium	E	+
Uterus	Smooth muscle cells of the myometrium	M	+
Testicle	Spermatogonia	M			+
Testicle	Spermatids	M	Midpiece
Prostate	Secretory epithelium	E	+	+	+	+
Lungs	Epithelium of the bronchioles	E	+	+
Spleen, lymph nodes	Dendritic cells	M	+		+
Spleen, lymph nodes	Macrophages in the wall of ellipsoids	M	+
Blood vessels	Endothelium	E	+
Blood vessels	Smooth muscle cells	M	+
Cerebral cortex	Oligodendrocytes	N	+		+
Cerebellum	Purkinje neurons	N	+
Cerebellum	Oligodendrocytes	N	+		+
Spinal cord	Oligodendrocytes	N	+		+
Peripheral nerves	Schwann cells	N	+		+
Schwann cell culture		N	+		+	+

^aThe cytoplasmic staining was mostly diffuse, but in some tissues, a distinct granular pattern was observed, such as the bile ducts and cells of the corpus luteum
Note: All the different cell types in a tissue were evaluated. Only positively stained cells are included in the table

ISSN: 1746-6148