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Fig. 1 | BMC Veterinary Research

Fig. 1

From: Indication of metabolic inflexibility to food intake in spontaneously overweight Labrador Retriever dogs

Fig. 1

Metabolite responses to food intake in lean and overweight dogs. Dogs were divided into two body condition groups: lean (BCS 4–5, n = 12) and overweight (BCS 6–8, n = 16), and the mixed model repeated measures analyses were applied. Values are given as liquid chromatography-time of flight mass spectrometry (LC-TOFMS) extracted ion chromatogram signal areas (mean ± SEM). Fasting plasma samples were taken 15 min before serving a test meal at time 0 (arrow) and metabolite signal areas in lean and overweight dogs are shown as response curves from fasting to 4 h after feeding. The overall carnitine (a) and acetylcarnitine (b) signal areas were lower in overweight compared with lean dogs. b At fasting, overweight dogs had lower plasma acetylcarnitine signal area than lean dogs. Lean dogs showed decreased acetylcarnitine signal area in response to food intake at one hour postprandially. Significant differences between time points (¤¤¤P < 0.001) and between body condition groups overall (**P < 0.01) are indicated. Different letters (a and b) indicate significant differences between body condition groups within time point (P < 0.05). In all dogs, propionylcarnitine (c) and stearoylcarnitine (d) increased in overall response to food intake, while vaccenylcarnitine (e) decreased (P ≤ 0.005 for all)

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