TY - JOUR AU - Söder, Josefin AU - Wernersson, Sara AU - Dicksved, Johan AU - Hagman, Ragnvi AU - Östman, Johnny R. AU - Moazzami, Ali A. AU - Höglund, Katja PY - 2019 DA - 2019/03/20 TI - Indication of metabolic inflexibility to food intake in spontaneously overweight Labrador Retriever dogs JO - BMC Veterinary Research SP - 96 VL - 15 IS - 1 AB - Obesity in dogs is an increasing problem associated with morbidity, shortened life span and poor life quality. Overweight dogs exhibit postprandial hyperlipidaemia, highlighting the need to identify potential dysregulations in lipid metabolism. This study investigated metabolites related to lipid metabolism (i.e. acylcarnitines and taurine) and phospholipids in a feed-challenge test and aimed to identify metabolic variations in spontaneously overweight dogs. Twenty-eight healthy male Labrador Retriever dogs were included, 12 of which were classified as lean (body condition score (BCS) 4–5 on a 9-point scale) and 16 as overweight (BCS 6–8). After overnight fasting (14–17 h), fasting blood samples were collected and dogs were fed a high-fat meal followed by postprandial blood sample collection hourly for 4 h. Liquid chromatography-time of flight mass spectrometry (LC-TOFMS) was used to identify plasma metabolites and phospholipids. Multivariate models, mixed model repeated measures and linear regression analyses were used for data interpretation. SN - 1746-6148 UR - https://doi.org/10.1186/s12917-019-1845-5 DO - 10.1186/s12917-019-1845-5 ID - Söder2019 ER -