Fig. 1

Maximum insulin and glucose responses (mean ± SE) measured in two groups of ponies after feeding a meal high in non-structural carbohydrates. Observations were made before the start of daily treatment with velagliflozin (0.3 mg/kg BW) or placebo (wk-0), during the middle and end of the treatment phase (wk 8 and 16), and 4 wk. after treatment ceased (wk-21). The maximum values represent either the 2 or 4 h measurement post-feeding. The dotted line represents a putative risk threshold for the development of insulin-induced laminitis. *P < 0.05 and ***P < 0.001 compared to corresponding group wk-0 pre-treatment values