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Fig. 3 | BMC Veterinary Research

Fig. 3

From: Dexamethasone-induced impairment of post-injury skeletal muscle regeneration

Fig. 3

The effect DEX on the repair phase of post-injury skeletal muscle regeneration. To establish this effect, the mean numbers of muscle precursor cells (MPCs) (a), myotubes (b) and young myofibres (c) were evaluated in BPVC-injured muscles of non-treated (control) and DEX-treated animals. The results represent the mean score (± SD) from 6 sites of muscle injury derived from 3 animals (2 independent muscle injuries per single animal) per group per day. The p-values (p < 0.05, p < 0.01, p < 0.001) refer to the significant differences between the groups at the same time point. Representative immunohistochemistry of post-injury myofibre regeneration sites. Day 1; Control: MyoD1-positive, not numerous MPCs. DEX: MyoD1-positive, single MPCs. Day 3; Control: desmin-positive, not numerous myotubes and myofibres. DEX: desmin-positive, numerous MPCs and myofibres, and the lack of positive myotubes. Day 14; Control: desmin-positive, numerous young myofibres. DEX: desmin positive, not numerous myotubes and numerous young myofibres. All sections were counterstained with haematoxylin (d)

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