Fig. 1
From: Dexamethasone-induced impairment of post-injury skeletal muscle regeneration
The effect of DEX on the inflammatory phase of post-injury skeletal muscle regeneration. To establish this effect, the presence and degree of extravasation (a), the presence and degree of necrosis (b), and presence and intensity of inflammation (c) were evaluated in the BPVC-injured muscles of non-treated (control) and DEX-treated animals. The results are expressed as the mean score (± SD) from 6 sites of muscle injury derived from 3 animals (2 independent muscle injuries per single animal) per group per day. The P-values (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001) refer to the significant differences between groups at the same time point. Representative H&E stained sections of post-injury myofibre regeneration sites. Day 1; Control: extensive necrosis, focal extravasation, and moderate inflammation. DEX: extensive necrosis and extravasation and moderate inflammation Day 7; Control: moderately numerous myotubes and numerous young myofibres. DEX: mild inflammation, numerous myotubes, and moderately numerous young myofibres. Day 14; Control: numerous young myofibres. DEX: Focal necrosis, mild inflammation, not numerous myotubes, and moderately numerous young myofibres (d)