Table 1 MIC of antibacterials in combination with mepyramine for E. coli ATCC® 25922™ and E. coli PIG 01
From: Histamine H1 receptor antagonists enhance the efficacy of antibacterials against Escherichia coli
Combination with MEP | MIC (μg/ml) | DRI Median | DRI Range | |||
|---|---|---|---|---|---|---|
Alone | Combined | |||||
Median | Range | Median | Range | |||
E. coli ATCC® 25922™ | ||||||
AMX | 1.5 | 1.5–2 | 1* | 1.0–1.5 | 1.5 | 1.3–1.5 |
SDZ/TMP | 2 | 1–4 | 1** | 0.3–1 | 3 | 2–8 |
TET | 0.5 | 0.5–0.5 | 0.3* | 0.3–0.5 | 2 | 1–2 |
CST | 8 | 8–8 | 1** | 1–2 | 8 | 4–8 |
ENR | 0.01 | 0.01–0.01 | 0.005** | 0.005–0.005 | 2 | 2–2 |
FFC | 8 | 8–16 | 2** | 2–4 | 4 | 4–4 |
GEN | 0.3 | 0.3–0.5 | 0.3 | 0.3–0.5 | 1 | 1–1 |
KA | 4 | 4.0–0.5 | 4 | 0.5–0.5 | 1 | 1–1 |
E. coli PIG 01 | ||||||
AMX | 1.5 | 1–3 | 1.3 | 0.8–2 | 1.5 | 1–1.5 |
SDZ/TMP | 2 | 2–4 | 2 | 1–2 | 1.5 | 1–2 |
TET | 1 | 1–4 | 0.5* | 0.5–1 | 2 | 2–4 |
CST | 2 | 2–4 | 1.5 | 1–2 | 2 | 1–4 |
ENR | 16 | 16–16 | 8 | 8–16 | 2 | 1–2 |
FFC | 8 | 8–32 | 2** | 2–4 | 4 | 4–8 |
GEN | 0.5 | 4–4 | 0.5 | 4–4 | 1 | 1–1 |
KAN | 8 | 4–8 | 8 | 4–8 | 1 | 1–1 |