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Table 1 MIC of antibacterials in combination with mepyramine for E. coli ATCC® 25922™ and E. coli PIG 01

From: Histamine H1 receptor antagonists enhance the efficacy of antibacterials against Escherichia coli

Combination with MEP MIC (μg/ml) DRI Median DRI Range
Alone Combined
Median Range Median Range
E. coli ATCC® 25922™
 AMX 1.5 1.5–2 1* 1.0–1.5 1.5 1.3–1.5
 SDZ/TMP 2 1–4 1** 0.3–1 3 2–8
 TET 0.5 0.5–0.5 0.3* 0.3–0.5 2 1–2
 CST 8 8–8 1** 1–2 8 4–8
 ENR 0.01 0.01–0.01 0.005** 0.005–0.005 2 2–2
 FFC 8 8–16 2** 2–4 4 4–4
 GEN 0.3 0.3–0.5 0.3 0.3–0.5 1 1–1
 KA 4 4.0–0.5 4 0.5–0.5 1 1–1
E. coli PIG 01
 AMX 1.5 1–3 1.3 0.8–2 1.5 1–1.5
 SDZ/TMP 2 2–4 2 1–2 1.5 1–2
 TET 1 1–4 0.5* 0.5–1 2 2–4
 CST 2 2–4 1.5 1–2 2 1–4
 ENR 16 16–16 8 8–16 2 1–2
 FFC 8 8–32 2** 2–4 4 4–8
 GEN 0.5 4–4 0.5 4–4 1 1–1
 KAN 8 4–8 8 4–8 1 1–1
  1. Data are expressed as median and range (n = 6)
  2. Statistical significances were assessed between MIC alone and combined
  3. AMX Amoxicillin, SDZ/TMP Sulfadiazine/trimethoprim, TET Tetracycline, CST Colistin, ENR Enrofloxacin, FFC Florfenicol, GEN Gentamicin, KAN Kanamycin, MEP Mepyramine, MIC Minimum inhibitory concentration, DRI Dose reduction index (MICalone / MICcombined)
  4. *Significantly different (p < 0.05), **Significantly different (p < 0.01)