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Table 1 Distribution of PrPCWD deposits in lymphoid tissues of clinically affected and non-inoculated white-tailed deer

From: Prion protein polymorphisms associated with reduced CWD susceptibility limit peripheral PrPCWD deposition in orally infected white-tailed deer

 

Non-inoculated

Genotype

wt/wt

S96/wt

H95/wt

H95/S96

wt/wt

D1

D2

D3

D4a

D5

D6

D7

D8

D9

D10

D11

D12

Retropharyngeal LN

++

+++

+++

/

++

++

++

+++

++

+++

–

–

Submandibular LN

+++

++

++

/

+++

++

++

++

/

/

–

–

Axillary LN

++

++

+

/

+++

++

++

–

++

+

–

–

Prescapular LN

+

+

+

/

++

+

–

–

+

++

–

–

Prefemoral LN

++

+

++

/

+

+

+

–

+

++

–

–

Popliteal LN

+

+

++

/

+++

+

+

+

+

+

–

–

Inguinal LN

+

+

++

/

+++

+

+

–

/

++

–

–

Tracheobronchial LN

++

+

+++

/

+++

/

/

/

/

/

–

–

Ileocecal LN

/

++

++

/

+++

++

+++

++

++

+++

–

–

Hepatic LN

/

+++

/

/

/

++

++

+++

+++

+++

/

/

Pancreatic LN

+++

/

/

/

/

++

+++

/

/

/

–

/

Adrenal LN

+++

++

/

/

–

++

+++

++

/

++

/

–

Spleen

+

+

+

+

+

–

+

+

+

+

–

–

3rd eyelid

+

+

++

/

-b

- b

- b

+

/

+

–

–

Tonsil

+++

+++

+++

+++

+++

+++

+++

+++

+++

+++

–

–

Peyer’s Patches

+++

+++

+++

+++

+++

+++

+++

/

+++

+++

–

–

Rectal lymphoid follicles

+++

+++

+++

+++

++

+++

+

/

/

+++

–

–

  1. PrPCWD deposition was detected by IHC
  2. aNo lymph nodes were collected from D4 bNo lymphoid follicles were present in the histological sample. / Sample not available for evaluation