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Table 1 Distribution of PrPCWD deposits in lymphoid tissues of clinically affected and non-inoculated white-tailed deer

From: Prion protein polymorphisms associated with reduced CWD susceptibility limit peripheral PrPCWD deposition in orally infected white-tailed deer

  Non-inoculated
Genotype wt/wt S96/wt H95/wt H95/S96 wt/wt
D1 D2 D3 D4a D5 D6 D7 D8 D9 D10 D11 D12
Retropharyngeal LN ++ +++ +++ / ++ ++ ++ +++ ++ +++
Submandibular LN +++ ++ ++ / +++ ++ ++ ++ / /
Axillary LN ++ ++ + / +++ ++ ++ ++ +
Prescapular LN + + + / ++ + + ++
Prefemoral LN ++ + ++ / + + + + ++
Popliteal LN + + ++ / +++ + + + + +
Inguinal LN + + ++ / +++ + + / ++
Tracheobronchial LN ++ + +++ / +++ / / / / /
Ileocecal LN / ++ ++ / +++ ++ +++ ++ ++ +++
Hepatic LN / +++ / / / ++ ++ +++ +++ +++ / /
Pancreatic LN +++ / / / / ++ +++ / / / /
Adrenal LN +++ ++ / / ++ +++ ++ / ++ /
Spleen + + + + + + + + +
3rd eyelid + + ++ / -b - b - b + / +
Tonsil +++ +++ +++ +++ +++ +++ +++ +++ +++ +++
Peyer’s Patches +++ +++ +++ +++ +++ +++ +++ / +++ +++
Rectal lymphoid follicles +++ +++ +++ +++ ++ +++ + / / +++
  1. PrPCWD deposition was detected by IHC
  2. aNo lymph nodes were collected from D4 bNo lymphoid follicles were present in the histological sample. / Sample not available for evaluation