Fig. 1
From: Highly invasive and poorly differentiated corneal squamous cell carcinoma in a dog
a Exophytic white irregular mass occupying 70% of the central cornea. b and c Subgross photography of partial eye and cornea respectively (H-E and Cytokeratin). Neoplastic cells produce epithelium disruption and deep corneal stromal invasion. Inset: Detail of the neoplastic corneal epithelium reacted with the CK5. d A proliferation of epithelial cells arranged in tubules was extending throughout the substantia propria of the cornea. Inset: Detail of the tubular structures surrounded by cells positive to muscle actin antibody (myofibroblasts). e Neoplastic cells arranged in tubules with prominent nucleoli, anisokaryosis and anisocytosis. The mitotic figures were moderate (arrowhead) H-E