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Table 2 PK parameters for danofloxacin in pig plasma after i.m. administration at a dose of 2.5 mg/kg (n = 6)

From: Susceptibility breakpoint for Danofloxacin against swine Escherichia coli

PK parameter

Unit

Mean ± SD

A

μg/mL

2.09 ± 1.46

B

μg/mL

0.41 ± 0.17

α

1/h

0.81 ± 0.41

β

1/h

0.10 ± 0.02

Ka

1/h

2.00 ± 0.51

K10

1/h

0.25 ± 0.08

K12

1/h

0.32 ± 0.20

K21

1/h

0.34 ± 0.23

T1/2Ka

h

0.37 ± 0.09

T1/2α

h

1.07 ± 0.60

T1/2β

h

7.28 ± 1.10

AUC

h*μg/mL

5.25 ± 1.35

Tmax

h

0.97 ± 0.08

Cmax

μg/mL

0.76 ± 0.08

CL

L/h

7.75 ± 1.74

Vc

liter/kg

2.28 ± 0.39

Vp

liter/kg

2.16 ± 0.86

Vss

liter/kg

4.17 ± 0.76

  1. A and B: Y-axis intercept terms; α: distribution rate constant; β: elimination rate constant; Ka: absorption rate constant; K10: central compartment elimination rate constant; K12: rate constant from central to peripheral compartment; K21: rate constant from peripheral to central compartment; T1/2Ka: absorption half-life of the drug; T1/2α: distribution half-life of the drug; T1/2β: elimination half-life of the drug; AUC: area under the curve of plasma concentration-time; Tmax: the time point of maximum plasma concentration of the drug; Cmax: the maximum plasma concentration; CL: body clearance; Vc: volume of distribution in the central compartment; Vp: volume of distribution; Vss: volume of distribution at steady state
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BMC Veterinary Research

ISSN: 1746-6148

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