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Table 3 Stepwise multivariate Cox regression analysis

From: Prognostic significance of circulating microRNA-214 and -126 in dogs with appendicular osteosarcoma receiving amputation and chemotherapy

  Long-term DFS 1-year DFS Long-term OS 1-year OS
P-value HR 95%CI P-value HR 95%CI P-value HR 95%CI P-value HR 95%CI
miR-214 High
(ACRQ, 0.92<)
0.0004 *** 3.51 1.68–8.55 0.001 *** 4.24 1.69–14.21 0.005 ** 2.95 1.35–7.77 0.013 * 3.17 1.25–10.71
miR-126 Low
(ACRQ, < 1.4)
0.003 ** 8.09 1.75–143.59
ALP High
(U/L, 96<)
0.007 ** 2.26 1.26–4.06 0.0047 ** 2.6 1.34–5.15
Model fitness 0.0004 *** < 0.0001 *** 0.0002 *** 0.0003 ***
  1. Stepwise multivariate Cox regression analysis identified independent variables for the prediction of the DFS and OS. P-values less than 0.05 were considered to be significant (*P < 0.05, **P < 0.01, ***P < 0.001). HR, hazard ratio; 95% CI, 95% confidential interval